ArticleBrain communications2026
Anxiety modulates odour-linked brain connectivity and alcohol dependence risk.
Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Alcohol use disorder (AUD) often emerges in adolescence and young adulthood, yet early neural predictors remain scarce. The olfactory system, through its connections with limbic and reward circuits, may provide a novel window into compulsive alcohol use. These brain regions are altered in AUD, but the role of olfactory pathways is poorly understood. Anxiety, a common comorbidity in AUD, may further modulate these circuits. This study investigates whether anxiety moderates the relationship between olfactory-reward brain connectivity and risky alcohol use and dependence. We analysed multimodal data from 1003 participants (22-36 years) in the Human Connectome Project. Resting-state functional MRI was used to compute functional connectivity among 41 regions implicated in olfaction, emotion, memory and reward. Odour identification scores were used to isolate connectivity features most correlated with olfactory function. These features served as predictors in ElasticNet and LASSO classification models for three alcohol-related outcomes: (i) lifetime
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