Evidence map›Paper›PMID 41907313›Full record

ArticleBrain communications2026

Dual mechanism of anti-seizure medications in controlling seizure activity.

Guillermo M Besné, Emmanuel Molefi, Billy Smith, Nathan Evans, Sarah J Gascoigne, Chris Thornton, Fahmida A Chowdhury, Beate Diehl, John S Duncan, Andrew W McEvoy and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Guillermo M BesnéCNNP Lab (www.cnnp-lab.com), School of Computing, Newcastle University, Newcastle upon Tyne NE4 5TG, United Kingdom.
Emmanuel MolefiCNNP Lab (www.cnnp-lab.com), School of Computing, Newcastle University, Newcastle upon Tyne NE4 5TG, United Kingdom.
Billy SmithCNNP Lab (www.cnnp-lab.com), School of Computing, Newcastle University, Newcastle upon Tyne NE4 5TG, United Kingdom.
Nathan EvansCNNP Lab (www.cnnp-lab.com), School of Computing, Newcastle University, Newcastle upon Tyne NE4 5TG, United Kingdom.
Sarah J GascoigneCNNP Lab (www.cnnp-lab.com), School of Computing, Newcastle University, Newcastle upon Tyne NE4 5TG, United Kingdom.
Chris ThorntonCNNP Lab (www.cnnp-lab.com), School of Computing, Newcastle University, Newcastle upon Tyne NE4 5TG, United Kingdom.
Fahmida A ChowdhuryDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom.
Beate DiehlDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom.
John S DuncanDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom.ORCID https://orcid.org/0000-0002-1373-0681
Andrew W McEvoyDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom.
Anna MiserocchiDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom.
Jane de TisiDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom.
Matthew C WalkerDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom.ORCID https://orcid.org/0000-0002-0812-0352
Peter N TaylorCNNP Lab (www.cnnp-lab.com), School of Computing, Newcastle University, Newcastle upon Tyne NE4 5TG, United Kingdom.ORCID https://orcid.org/0000-0003-2144-9838
Yujiang WangCNNP Lab (www.cnnp-lab.com), School of Computing, Newcastle University, Newcastle upon Tyne NE4 5TG, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anti-seizure medications (ASMs) can reduce seizure duration, but their precise modes of action are unclear. Specifically, it is unknown whether ASMs shorten seizures by curtailing existing seizure activity early or by selectively suppressing certain seizure activity patterns from emerging. We retrospectively analysed intracranial EEG (iEEG) recordings of 457 seizures from 28 people with epilepsy undergoing ASM tapering. Beyond measuring seizure occurrence and duration, we categorized distinct seizure propagation activity patterns (states) based on spatial and frequency power characteristics and related these to different ASM levels. We found that reducing ASM levels led to increased seizure frequency (

Indexed as

bifurcationdynamic statesneurophysiologyseizure propagationseizure states

Identifiers

PMID41907313
PMCPMC13023363

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.