Evidence map›Paper›PMID 41907310›Full record

ArticleBrain and environment2026

Neighborhood social fragmentation and cerebello-thalamo-cortical connectivity in youth at clinical high-risk for psychosis and healthy comparisons.

Benson S Ku, Ella J Arrant, Jean Addington, Carrie E Bearden, Kristin S Cadenhead, Tyrone D Cannon, Ricardo E Carrion, Matcheri S Keshavan, Daniel H Mathalon, William S Stone and 4 more

Abstract read
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In one paragraph

Article in Brain and environment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Benson S KuDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 100 Woodruff Circle, Atlanta, GA 30322, USA.ORCID 0000-0001-6994-8770
Ella J ArrantDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 100 Woodruff Circle, Atlanta, GA 30322, USA.
Jean AddingtonDepartment of Psychiatry, Hotchkiss Brain Institute, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada.
Carrie E BeardenDepartments of Psychiatry and Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90095, USA.
Kristin S CadenheadDepartment of Psychiatry, University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Tyrone D CannonDepartment of Psychiatry, Yale University School of Medicine, 300 George Street, New Haven, CT 06511, USA.
Ricardo E CarrionDivision of Psychiatry Research, Zucker Hillside Hospital, 75-59 263 Street, Glen Oaks, NY 11004, USA.
Matcheri S KeshavanDepartment of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA.
Daniel H MathalonDepartment of Psychiatry & Behavioral Sciences, University of California, San Francisco, 675, 18th Street, San Francisco, CA 94143, USA.
William S StoneDepartment of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA.
Scott W WoodsDepartment of Psychiatry, Yale University School of Medicine, 300 George Street, New Haven, CT 06511, USA.
Elaine F WalkerDepartment of Psychology, Emory University, 36 Eagle Row, Atlanta, GA 30322, USA.
Diana O PerkinsDepartment of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, 333, S Colombia Street, Suite 304, Chapel Hill, NC 27514, USA.
Hengyi CaoDivision of Psychiatry Research, Zucker Hillside Hospital, 75-59 263 Street, Glen Oaks, NY 11004, USA.

Funding

STRESS AND EMOTIONAL REACTIVITYP50MH066286 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NUECHTERLEIN, KEITH H · 2003 to 2014
$18.6M
1/9 Predictors and Mechanisms of Conversion to PsychosisU01MH081902 · NIMH · YALE UNIVERSITY · PI CANNON, TYRONE D · 2008 to 2018
$12.4M
4/9-Predictors and Mechanisms of Conversion to PsychosisU01MH081857 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI CORNBLATT, BARBARA A. · 2008 to 2018
$6.2M
8/9 Predictors and Mechanisms of Conversion to PsychosisU01MH082022 · NIMH · YALE UNIVERSITY · PI WOODS, SCOTT W · 2008 to 2018
$6.0M
2/9 - Predictors and Mechanisms of Conversion to PsychosisU01MH081988 · NIMH · EMORY UNIVERSITY · PI WALKER, ELAINE FRAN · 2008 to 2018
$5.4M
6/9-Predictors and Mechanisms of Conversion to PsychosisU01MH081944 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CADENHEAD, KRISTIN S. · 2008 to 2018
$4.9M
Functional Brain Abnormalities in the Schizophrenia ProdromeR01MH076989 · NIMH · YALE UNIVERSITY · PI MATHALON, DANIEL H · 2007 to 2014
$2.3M
Enhancing the Prospective Prediction of PsychosisU01MH066069 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PERKINS, DIANA O. · 2003 to 2007
$1.5M
Cerebellar-Cortical Circuitry and Treatment Response in Early PsychosisR01MH137501 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI Hengyi Cao · 2025 to 2026
$980k
Impact of Neighborhood Characteristics on Conversion to Psychosis among Youth at Clinical High Risk for PsychosisK23MH129684 · NIMH · EMORY UNIVERSITY · PI Benson Ku · 2022 to 2026
$970k
Enhancing the Prospective Prediction of PsychosisU01MH066134 · NIMH · CENTRE FOR ADDICTION AND MENTAL HEALTH · PI ADDINGTON, JEAN M · 2003 to 2007
$869k
Development of Cerebellar-Cortical Functional Connectivity in Youth and Its Prediction of PsychosisR01MH138682 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI Hengyi Cao · 2025 to 2026
$854k
NIMH NIH HHS K23 MH129684NIMH NIH HHS P50 MH066286NIMH NIH HHS R01 MH076989NIMH NIH HHS R01 MH137501NIMH NIH HHS R01 MH138682NIMH NIH HHS U01 MH066069NIMH NIH HHS U01 MH066134NIMH NIH HHS U01 MH081857NIMH NIH HHS U01 MH081902NIMH NIH HHS U01 MH081944NIMH NIH HHS U01 MH081988NIMH NIH HHS U01 MH082022
6 · The paper itself

Abstract

Hyperconnectivity in the cerebello-thalamo-cortical (CTC) circuit, a key component of predictive coding, has been linked to schizophrenia and psychosis risk among youth at clinical high-risk for psychosis (CHR-P). The cerebellum monitors prediction errors, and its dysfunction may lead to misattributions of internal experiences and, consequently, hallucinations and delusions. Neighborhood social fragmentation, characterized by disrupted social ties and unpredictable norms, may compromise the brain's ability to form stable models of the social world. Within predictive coding frameworks, such environments can hinder belief updating, increasing reliance on prior beliefs. This maladaptive process may disrupt CTC connectivity, thereby increasing vulnerability to psychosis. This study examined whether neighborhood social fragmentation predicted CTC connectivity in CHR-P and healthy comparison (HC) youth using functional connectivity data from the North American Prodrome Longitudinal Study Phase 2. Generalized linear mixed models assessed associations between social fragmentation and CTC connectivity, adjusting for age, sex, race/ethnicity, individual poverty, neighborhood educational attainment (proportion of residents with <9

Indexed as

Adolescencecerebello-thalamo-cortical connectivity (CTC)clinical high risk for psychosis (CHR-P)neurodevelopmentsocial fragmentation

Identifiers

PMID41907310
PMCPMC13030900

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.