ArticleJournal of cancer immunology2025
Adherent Natural Killer Cells De Novo Express IL-2Rα and Sustain Long-Lasting, Potent Anti-Tumor Activity in Picomolar Concentrations of IL-2.
Article in Journal of cancer immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Natural killer (NK) cells are innate lymphoid cells (ILCs) that play key roles in immunosurveillance and immunoregulation. They constitute a heterogeneous population comprising three principal subpopulations: NK1 (cytotoxic), NK2 (regulatory), and NK3 (adaptive). In response to interleukin-2 (IL-2) stimulation, NK3 cells differentiate into adherent NK (A-NK) cells, which exhibit potent anti-tumor activity. Human A-NK cells are generated by priming and adherence-based selection of peripheral blood NK3 cells in nanomolar (nM) IL-2 concentrations, followed by prolonged restimulation and culture in the same IL-2 conditions. However, these A-NK cells are terminally differentiated, unresponsive to IL-2, prone to apoptosis, and are ineffective in cancer therapy. Here, we report previously unrecognized physiological properties of A-NK cells and describe a novel strategy for their
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