ArticleFrontiers in medicine2026
Histological signatures of hormone replacement therapy in the endometrium.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Hormone replacement therapy (HRT) is widely prescribed for managing menopausal symptoms, yet its effects on the endometrium remain clinically important. While large-scale studies have established that estrogen-only HRT increases endometrial cancer risk and continuous combined regimens reduce this risk, real-world data on endometrial histology remain valuable for understanding contemporary practice patterns. Methods: We conducted a retrospective analysis of women who underwent hysteroscopy with endometrial sampling at Princess Royal University Hospital. Of the 62 patients, we included 24 (38.7%) with explicitly documented HRT status, excluding 38 (61.3%) whose HRT status was unknown or inadequately documented. We characterized HRT regimens by type, route, schedule, and duration when available. Histological findings were compared between HRT users ( Results: Among 24 patients (mean age 57.3 ± 6.8 years), 13 (54.2%) received HRT, and 11 (45.8%) did not. HRT regimens included combined estrogen-progestogen therapy ( Conclusion: In this retrospective case series, no endometrial hyperplasia or cancer was identified among 24 women with documented HRT status. However, the study was severely underpowered to detect rare but clinically significant pathologies. The absence of abnormal findings likely reflects the small sample size and low baseline incidence, rather than a protective effect. The high rate of missing HRT documentation (61.3%) represents a significant quality gap. These findings underscore the limitations of small retrospective series and highlight the need for adequately powered, prospective studies with systematic HRT characterization.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.