Evidence map›Paper›PMID 41907242›Full record

ReviewFrontiers in medicine2026

Advancements in AI-based quantitative analysis of fundus tessellation and its application in myopia research.

Yi-Ming Guo, Tian Zhan, Jing Zheng, Junhan Wei, Jiaqi Wang, Yijin Han, Juan Huang, Xingye Wang, Guoyun Zhang, Lu Ye

Abstract readReview
In one paragraph

Review in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yi-Ming GuoShaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated People's Hospital of Northwest University, Xi'an, China.
Tian ZhanShaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated People's Hospital of Northwest University, Xi'an, China.
Jing ZhengShaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated People's Hospital of Northwest University, Xi'an, China.
Junhan WeiShaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated People's Hospital of Northwest University, Xi'an, China.
Jiaqi WangShaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated People's Hospital of Northwest University, Xi'an, China.
Yijin HanShaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated People's Hospital of Northwest University, Xi'an, China.
Juan HuangShaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated People's Hospital of Northwest University, Xi'an, China.
Xingye WangEVision Technology (Beijing) Co. Ltd., Beijing, China.
Guoyun ZhangShaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated People's Hospital of Northwest University, Xi'an, China.
Lu YeShaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated People's Hospital of Northwest University, Xi'an, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Fundus tessellation (FT) is increasingly recognized as an early structural manifestation of retinal and choroidal remodeling in myopia, reflecting initial changes associated with axial elongation. With advances in artificial intelligence (AI), particularly deep learning-based image analysis, quantitative assessment of FT has emerged as a promising approach for objective and scalable evaluation in myopia research. Methods: This review provides an integrative overview of recent studies applying AI-assisted and quantitative image-analysis approaches to fundus tessellation assessment. Relevant literature was identified through a structured search of major biomedical databases, focusing on methodologies for FT and fundus tessellation density (FTD) quantification and their reported associations with clinical ocular parameters in myopia. Results: Across multiple cohorts, AI-derived FTD consistently showed associations with axial length elongation, choroidal thinning, and increasing myopia severity. Common analytical frameworks involved region-of-interest definition, image normalization, and supervised deep learning-based segmentation. Several studies further reported spatial heterogeneity in FTD distribution and its relationship with peripapillary and macular alterations, supporting the potential role of FT-related metrics as quantitative imaging biomarkers for myopic structural change. Conclusion: AI-driven quantification of fundus tessellation represents a methodological advancement in myopia research by enhancing objectivity and scalability in retinal image analysis. These approaches may facilitate early risk stratification and hold promise for future longitudinal assessment of myopia.

Indexed as

artificial intelligenceaxial lengthfundus tessellationfundus tessellation densitymyopia

Identifiers

PMID41907242
PMCPMC13021487

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.