ArticleNon-coding RNA research2026
Hsa_circ_0101645 contributes to excessive autophagy and apoptosis in intervertebral disc degeneration by acting as a miR-1304-5p sponge modulating BNIP3 expression.
Article in Non-coding RNA research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Mechanotransduction in intervertebral disc degeneration: from compartment-specific sensors to translational frontiers.Frontiers in bioengineering and biotechnology · 2026Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Intervertebral disc (IVD) degeneration (IVDD) is the pathological foundation and principal cause for degenerative spine related diseases. Currently, its molecular pathogenesis and reliable biomarkers remain poorly understood. This study intends to elucidate the potential molecular mechanisms of circular RNAs (circRNAs) in IVDD, and to identify novel targeted therapeutic strategies. Methods: Differentially expressed circRNAs (DE-circRNAs) were obtained by a secondary analysis of the IVDD-related dataset GSE67566, followed by enrichment analysis of their host genes. Both Results: In the bioinformatics, there were 354 significantly down-regulated and 282 up-regulated DE-circRNAs in IVDD. The host genes of these circRNAs were mainly enriched in cell morphogenesis, autophagy, and apoptosis. In clinical samples, hsa_circ_0101645 in DE-circRNAs was markedly overexpressed in endplate chondrocytes (EPC) derived from IVDD patients and was predominantly localized in the cytoplasm. Conclusions: Hsa_circ_0101645 service as ceRNA that facilitates IVDD process by mediating proliferation, apoptosis, and excessive autophagy of CEP via the miR-1304-5p/BNIP3 axis. These findings suggest that hsa_circ_0101645 represents a promising molecular target for IVDD therapy.
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Registered trials
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