Evidence map›Paper›PMID 41907042›Full record

ArticleOpen life sciences2026

TRIM28-mediated p53 ubiquitination inhibits trophoblast apoptosis to support normal placental development.

Huixiang Qian, Ruping Quan, Juan Chen, Yanghong Liu, Jing Hu, Ruizhen Li, Chao Lv

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Huixiang QianDepartment of Obstetrics and Gynecology, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan Province, China.
Ruping QuanInstitute of Reproductive & Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, 410013, Hunan Province, China.
Juan ChenOutpatient Department, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan Province, China.
Yanghong LiuDepartment of Obstetrics and Gynecology, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan Province, China.
Jing HuDepartment of Obstetrics and Gynecology, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan Province, China.
Ruizhen LiDepartment of Obstetrics and Gynecology, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan Province, China.
Chao LvDepartment of Obstetrics and Gynecology, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tripartite motif-containing 28 (TRIM28), a transcriptional regulatory factor, is involved in various biological processes. However, its role in early-onset preeclampsia (EOPE) remains unclear. An EOPE mouse model was established using Nω-Nitro-L-arginine methyl ester (L-NAME), while TRIM28 or tumor protein p53 (p53) expression was modulated through lentiviral infections. Maternal blood pressure and urinary protein levels were measured. Placental tissues were collected at embryonic day 17.5 for hematoxylin-eosin staining, immunohistochemistry, Western blot, and real-time quantitative polymerase chain reaction.

Indexed as

apoptosisp53 ubiquitinationplacental developmentpregnancyTRIM28

Identifiers

PMID41907042
PMCPMC13022938

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.