ArticleUltrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology2026
Placental insufficiency markers to assess the risk of non-chromosomal genetic conditions in early-onset fetal growth restriction.
Article in Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo assess the value of placental insufficiency markers for estimating the risk of genetic anomalies in fetuses with isolated early-onset fetal growth restriction (FGR), defined as an estimated fetal weight ≤ 3
methodsWe performed a retrospective analysis of data collected prospectively from cases that attended Vall d'Hebron University Hospital, Barcelona, Spain, between February 2016 and December 2022. Singleton pregnancies diagnosed with isolated early-onset FGR between 20 + 0 and 28 + 6 weeks' gestation were eligible for inclusion. Cases in which a pathogenic or likely pathogenic fetal genetic abnormality was detected by chromosomal microarray (CMA) or whole-exome sequencing (WES) were identified. Cases were stratified by soluble fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor (PlGF) ratio (< 38 vs ≥ 38), PlGF level (< 100 vs ≥ 100 pg/mL), mean uterine artery (UtA) pulsatility index (PI) (< 95
resultsIn the total cohort of 238 cases of isolated early-onset FGR, seven (2.9%) cases of genetic anomaly were detected. Of these, 2/7 (28.6%) were detected by prenatal or postnatal CMA and 5/7 (71.4%) by postnatal WES. Fetal Doppler alone and UtA-PI alone did not identify subgroups with a significantly different prevalence of genetic abnormality compared with the overall cohort. In contrast, a sFlt-1/PlGF ratio < 38 and PlGF level ≥ 100 pg/mL defined subgroups with a significantly higher prevalence of genetic abnormality, while no genetic anomalies were found in cases with a sFlt-1/PlGF ratio ≥ 38 or PlGF level < 45 pg/mL. Furthermore, smaller subgroups combining markers of placental insufficiency identified cases at significantly higher or lower risk of FGR-related genetic anomaly.
conclusionsPlacental insufficiency markers, particularly the sFlt-1/PlGF ratio and PlGF level, may enable refined risk stratification of genetic anomalies in cases of isolated early-onset FGR, which could be used to provide individualized prenatal counseling and to optimize the use of WES. Furthermore, combining markers of placental insufficiency, such as UtA-PI and fetal Doppler, may improve risk stratification, potentially defining smaller subgroups with a higher prevalence of genetic anomalies, for which WES may provide greater diagnostic yield. © 2026 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.