Evidence map›Paper›PMID 41906940›Full record

ArticleParasite immunology2026

Transcriptomic and Proteomic Analyses Show Minimal Role for ST2 on MCPT5-Expressing Mast Cells in Primary Heligmosomoides polygyrus bakeri Infection.

Nicole W P Ong, Suzanne H Hodge, Christa P Baker, Danielle J Smyth, Tania Frangova, Henry J McSorley

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasite immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nicole W P OngDivision of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, UK.
Suzanne H HodgeDivision of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, UK.
Christa P BakerDivision of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, UK.
Danielle J SmythDivision of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, UK.
Tania FrangovaDivision of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, UK.
Henry J McSorleyDivision of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, UK.

Funding

Wellcome Trust 221914/Z/20/ZWellcome Trust 224014/Z/21/Z
6 · The paper itself

Abstract

The IL-33/ST2 pathway is important as part of the type 2 immune response against helminth infections. Mast cells express the highest levels of the IL-33 receptor subunit ST2 of any immune cell, and mast cells can mediate type 2 immune inflammation; however, the role of IL-33-driven mast cell responses in helminth infection is poorly understood. We sought to determine the role of mast cell ST2 expression during Heligmosomoides polygyrus bakeri (Hpb) infection by generating mast cell conditional ST2 knockout (MCPT5

Indexed as

Interleukin-1 Receptor-Like 1 ProteinMast CellsNematospiroides dubiusStrongylida InfectionsAnimalsFemaleGene Expression ProfilingImmunoglobulin EInterleukin-33MiceMice, KnockoutProteomicsIl1rl1 protein, mouseImmunoglobulin EInterleukin-1 Receptor-Like 1 ProteinInterleukin-33Heligmosomoides polygyrus bakeriIL‐33interleukin‐33mast cellproteomicsST2transcriptomics

Identifiers

PMID41906940
PMCPMC13034402

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.