Evidence map›Paper›PMID 41906642›Full record

ArticleEuropean journal of immunology2026

Deletion of Lymphatic PD-L1 Protects Mice From Severe Autoimmune Encephalitis.

Ziyuan Wang, Elèni Meuffels, Christian Ashworth, Emma Reynaud, Shruthi Hemanna, Burkhard Becher, Michael Detmar, Sarah Mundt, Lothar C Dieterich

Erratum issuedAbstract read
In one paragraph

Article in European journal of immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Ziyuan WangEuropean Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
Elèni MeuffelsInstitute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
Christian AshworthInstitute of Experimental Immunology, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-4206-9490
Emma ReynaudEuropean Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
Shruthi HemannaEuropean Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
Burkhard BecherInstitute of Experimental Immunology, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-1541-7867
Michael DetmarInstitute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH) Zurich, Zurich, Switzerland.
Sarah MundtInstitute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
Lothar C DieterichEuropean Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.ORCID 0000-0001-7908-5710

Funding

Chinese Scholarship Council fellowship (CSC) 202308310037Deutsche Forschungsgemeinschaft (DFG) 492531042Deutsche Forschungsgemeinschaft (DFG) 543385151Research Talent Development Fund zur Förderung des akademischen NachwuchsesSwiss National Science Foundation Ambizione (SNSF) PZ00P3_193330
6 · The paper itself

Abstract

Lymphatic endothelial cells at the cribriform plate and in brain-draining cervical lymph nodes express PD-L1 during autoimmune encephalitis. Unexpectedly, deletion of lymphatic PD-L1 expression ameliorates disease symptoms and is associated with increased brain infiltration of regulatory CD8+ Foxp3+ T cells.

Indexed as

B7-H1 AntigenEncephalitisHashimoto DiseaseAnimalsBrainCD8-Positive T-LymphocytesEndothelial CellsForkhead Transcription FactorsGene DeletionLymph NodesMiceMice, Inbred C57BLMice, KnockoutT-Lymphocytes, RegulatoryB7-H1 AntigenCd274 protein, mouseForkhead Transcription FactorsFoxp3 protein, mouse

Identifiers

PMID41906642
PMCPMC13033968

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.