Evidence map›Paper›PMID 41906621›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2026

Influence of OSCAR-IB criteria on test-retest reliability of Spectralis SD-OCT retinal thickness measurements in people with Multiple Sclerosis.

Anna Bacchetti, Brenna McCormack, Ting-Yi Lin, Angeliki G Filippatou, Georgios Gakis, Nicole Pellegrini, Evan Kinder, Ananya Gulati, Ernest Lievers, Gabriel Otero-Duran and 7 more

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In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Anna BacchettiDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0009-0000-9434-8531
Brenna McCormackDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0009-0002-6678-7021
Ting-Yi LinDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-9605-8095
Angeliki G FilippatouDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-0419-233X
Georgios GakisDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-7339-4659
Nicole PellegriniDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Evan KinderDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0009-0006-0683-4999
Ananya GulatiDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ernest LieversDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Gabriel Otero-DuranDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Scott D NewsomeDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-5284-4681
Olwen MurphyDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Neurology, Tallaght University Hospital, Dublin, Ireland.
Bardia NourbakhshDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-6617-2003
Kathryn C FitzgeraldDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-3137-0322
Elias S SotirchosDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-8812-1637
Peter A CalabresiDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-7776-6472
Shiv SaidhaDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-6387-0714

Funding

Imaging Neurodegeneration in Multiple SclerosisR01NS082347 · NINDS · JOHNS HOPKINS UNIVERSITY · PI PETER A CALABRESI, Shiv Saidha · 2013 to 2026
$7.0M
Prediction of risk of disability worsening and inflammatory disease activity in MS utilizing multimodal prediction algorithmsK23NS117883 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SOTIRCHOS, ELIAS S · 2020 to 2024
$918k
NINDS NIH HHS K23 NS117883NINDS NIH HHS R01 NS082347
6 · The paper itself

Abstract

backgroundOptical coherence tomography (OCT) enables evaluation of inter-eye differences (IEDs) in peri-papillary retinal nerve fiber layer (pRNFL) and macular ganglion cell-inner plexiform layer (GCIPL) thicknesses to identify unilateral optic nerve involvement (UONI), included in the 2024 revised McDonald diagnostic criteria for multiple sclerosis (MS).

objectivesTo evaluate pRNFL and GCIPL thickness test-retest reliability in scans fulfilling (SFO) versus not fulfilling (SNFO) OSCAR-IB criteria in people with MS using Spectralis SD-OCT.

methodsFrom 164 participants, two scans per eye per protocol (optic nerve head: pRNFL; macular volume: GCIPL) were obtained with Spectralis SD-OCT and classified as SFO or SNFO. Intra-visit intraclass correlation coefficients (ICCs) and coefficients of variation (COVs) quantified reproducibility.

resultspRNFL thicknesses from SNFO exhibited lower reliability (

conclusionsOSCAR-IB violations negligibly affected GCIPL reliability, although reduced pRNFL reliability, supporting quality control to avoid erroneous UONI, and suggesting that GCIPL measures may be more robust than pRNFL measures with Spectralis SD-OCT, in contrast to prior Cirrus HD-OCT studies.

Indexed as

Multiple SclerosisRetinaTomography, Optical CoherenceAdultFemaleHumansMaleMiddle AgedNerve FibersReproducibility of ResultsRetinal Ganglion Cellsinter-eye differencemultiple sclerosisOCTOSCAR-IB criteriareliabilitytest-retest

Identifiers

PMID41906621
PMCPMC13037678

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.