ArticleEuropean journal of immunology2026
Irgm1 Restrains CD8
Caitlyn T Molloy, Yazan Alwarawrah, Jonathan A Cohen, Brian E Fee, Jason K Whitmire, Gregory A Taylor, Nancie J MacIver
Abstract read
In one paragraphArticle in European journal of immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
7 authors.
Caitlyn T MolloyDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA.
Yazan AlwarawrahDepartment of Pediatrics, Division of Pediatric Endocrinology, University of North Carolina, Chapel Hill, North Carolina, USA.
Jonathan A CohenDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.
Brian E FeeDepartment of Medicine, Division of Geriatrics, and Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina, USA.
Jason K WhitmireDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA.
Gregory A TaylorDepartment of Medicine, Division of Geriatrics, and Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina, USA.
Nancie J MacIverDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA.ORCID 0000-0003-3676-9391 Funding
UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SUSAN M. SMITH · 1999 to 2026
$31.6MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007171 · NIGMS · DUKE UNIVERSITY · PI KONTOS, CHRISTOPHER D · 1985 to 2021
$31.2MVanderbilt Clinical Oncology Research Career Development ProgramK12CA090625 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Debra L. Friedman, Paula Jill Hurley · 2001 to 2026
$16.9MIRGM proteins as regulators of inflammationR01AI148243 · NIAID · DUKE UNIVERSITY · PI COERS, JOERN, TAYLOR, GREGORY A · 2020 to 2024
$2.4MRole of IRGM proteins in immunity to enteric bacteriaR01AI145929 · NIAID · DUKE UNIVERSITY · PI TAYLOR, GREGORY A · 2019 to 2023
$1.6MLeptin as a Regulator of T Cell Metabolism and FunctionK08DK087944 · NIDDK · DUKE UNIVERSITY · PI MACIVER, NANCIE · 2010 to 2014
$678kRegulation of T cell metabolism and function by IRGM proteinsR21AI135398 · NIAID · DUKE UNIVERSITY · PI MACIVER, NANCIE, TAYLOR, GREGORY A · 2019 to 2020
$442kMetabolic reprogramming to improve EGFRvIII CAR T cell persistenceR21CA253163 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MACIVER, NANCIE, SAMPSON, JOHN H. · 2021 to 2022
$402kNational Institute of Allergy and Infectious Diseases R21AI135398NCI NIH HHS K12 CA090625NCI NIH HHS R21 CA253163NIAID NIH HHS R01 AI145929NIAID NIH HHS R01 AI148243NIAID NIH HHS R21 AI135398NIDDK NIH HHS K08 DK087944NIDDK NIH HHS P30 DK056350NIGMS NIH HHS T32 GM007171
6 · The paper itselfAbstract
Immunity-related GTPases (IRGs) are a family of proteins that maintain cellular homeostasis by promoting autophagy and mitophagy. Mutations in human IRGM and genetic deletion of mouse Irgm1 have been linked to increased severity of inflammatory bowel disease, cancer, sepsis, and various infections. While IRGM/Irgm1 are known cell-intrinsic regulators of inflammation, their roles in T cell function remain poorly understood. We previously demonstrated that Irgm1 deficiency leads to increased production of proinflammatory mediators, including Granzyme B and interferon-γ, and increased apoptosis in CD8
Indexed as
ApoptosisCD8-Positive T-LymphocytesCytokinesGTP-Binding ProteinsInterferon Type ILymphocytic ChoriomeningitisAnimalsLymphocytic choriomeningitis virusMiceMice, Inbred C57BLMice, KnockoutSignal TransductionCytokinesGTP-Binding ProteinsIfi1 protein, mouseInterferon Type IapoptosisCD8+ T cellsimmunity‐related GTPase M1 (Irgm1)inflammationtype I interferon
Identifiers
PMID41906618
PMCPMC13078172
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