Evidence map›Paper›PMID 41906554›Full record

ArticleJACC. Case reports2026

Loss of Consciousness During Intense Exercise: Is It Hypotension or Not?

Michael G Leahy, Giorgio Manferdelli, Eric T Hedge, Keval D Patel, Jennifer K Whitham, Benjamin D Levine

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michael G LeahyInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, Texas, USA; Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Giorgio ManferdelliInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, Texas, USA; Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Eric T HedgeInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, Texas, USA; Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Keval D PatelInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, Texas, USA; Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Jennifer K WhithamDivision of Pediatric Cardiology, WakeMed Children's Hospital, Raleigh, North Carolina, USA.
Benjamin D LevineInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, Texas, USA; Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA. Electronic address: BenjaminLevine@TexasHealth.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAn 18-year-old female middle-distance runner was referred for loss of consciousness (LOC) during races. CASE SUMMARY: A treadmill exercise test was completed with direct, continuous measures of arterial blood pressure. We were able to elicit LOC during maximal exertion on 2 occasions. Beat-by-beat arterial pressure demonstrated that the LOC occurred despite having normal exercising blood pressure. DISCUSSION: We demonstrate an instructive case in which LOC during maximal exertion may be a consequence of an athlete exercising outside of their physiological limits in the absence of hypotension, causing cerebral hypoperfusion and subsequent syncope. TAKE-HOME MESSAGE: In highly motivated athletes, LOC may occur during maximal exercise in the absence of hypotension.

Indexed as

awarenessexercisehemodynamics

Identifiers

PMID41906554
PMCPMC13045592

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.