ArticleInternational journal of dermatology2026
Superior Clinical and Economic Value of IL-23 Inhibitors Versus Adalimumab Biosimilars in Plaque Psoriasis.
Article in International journal of dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Real-World Effectiveness and Safety of Tildrakizumab in a Large Spanish Multicenter Cohort from Spanish Psoriasis Group (GPS).Pharmacy (Basel, Switzerland) · 2026Article
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Authors and funding
14 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundIn recent years, the introduction of interleukin (IL)-23 inhibitors has revolutionized psoriasis treatment, allowing the majority of patients to achieve a long-term, complete clinical control of the disease. Nevertheless, there are no real-world studies exploring the cost benefit ratio of these new drugs compared to the currently most prescribed therapies as adalimumab biosimilars.
methodsWe performed a retrospective study to evaluate the clinical effectiveness, measured as Psoriasis Area and Severity Index (PASI)90-number needed to treat (NNT) and the cost-effectiveness of IL-23 inhibitors (guselkumab, risankizumab, tildrakizumab) in patients with moderate to severe psoriasis as compared to adalimumab biosimilars (imraldi, hyrimoz, yuflima, and amgevita). Assessments were performed at Weeks 16 and 52.
resultsOur analysis included 616 patients with moderate to severe psoriasis who had been treated with adalimumab biosimilars or an anti-IL-23 inhibitor for at least 16 weeks. Overall, IL-23 inhibitors were shown to be more effective compared to adalimumab biosimilars, with significantly lower NNT. Risankizumab achieved the highest PASI90 response rates, whereas guselkumab had the most favorable incremental cost per PASI90 responder at Weeks 16 and 52.
conclusionsOur study highlights the substantial clinical benefit of IL-23 inhibitors over adalimumab biosimilars, with guselkumab as the more cost-effective option than the other IL-23 inhibitors for the real-world management of moderate-to-severe psoriasis.
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