Interplay between uromodulin excretion and water balance in the general adult population.

David A Jaques, Théodore Pasquier, Menno Pruijm, Daniel Ackermann, Murielle Bochud, Olivier Devuyst, Belen Ponte

Abstract read

In one paragraph

Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Endocrine regulation of uromodulin in aging.Frontiers in endocrinology · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

David A JaquesDivision of Nephrology and Hypertension, Geneva University Hospitals, Geneva, Switzerland.ORCID 0000-0003-3841-3049

Théodore PasquierDivision of Internal Medicine, Geneva University Hospitals, Geneva, Switzerland.

Menno PruijmDivision of Nephrology and Hypertension, University of Lausanne and University Hospital of Lausanne, Lausanne, Switzerland.

Daniel AckermannDivision of Nephrology and Hypertension, Inselspital, Bern, Switzerland.

Murielle BochudDepartment of Epidemiology and Health Systems, University Center for Primary Care and Public Health (Unisanté), Lausanne, Switzerland.

Olivier DevuystDepartment of Physiology, Mechanisms of Inherited Kidney Disorders, University of Zurich, Zurich, Switzerland.

Belen PonteDivision of Nephrology and Hypertension, Geneva University Hospitals, Geneva, Switzerland.

Funding

European Reference Network for Rare Kidney Diseases Project 739532European Union's Horizon 2020 Research and Innovation Program under Marie Curie 860977Geneva University Hospitals PRD 10-2013-ISwiss National Science Foundation 310030-189044Swiss National Science Foundation FN 33CM30-124087

6 · The paper itself

Abstract

Uromodulin is a kidney-specific protein that is excreted in the normal urine. Factors regulating its excretion are unknown. Conflicting studies suggest that water balance may influence uromodulin excretion which, in turn, may cooperate with vasopressin to increase water reabsorption in the distal nephron. We analyzed the interplay between uromodulin excretion and water balance in a healthy adult population. Participants were recruited in a population-based study in Switzerland. The urine uromodulin excretion rate (UUER) (mg/24 h) was measured (ELISA) in parallel with urine osmolality and serum copeptin (pmol/L) (immune-luminometric assay) as a surrogate for vasopressin. Mixed multi-variate linear regression models were used. We included 937 participants with 497 (53.0%) women, median age 47.7 years (32.4-61.6) and 27 (2.8%) with eGFR <60 mL/min/1.73m

Indexed as

UromodulinWater-Electrolyte BalanceAdultFemaleGlycopeptidesHumansMaleMiddle AgedOsmolar ConcentrationVasopressinscopeptinsGlycopeptidesUromodulinVasopressinscopeptinurine osmolalityuromodulinvasopressinwater balance

Identifiers

PMID41906340

DOI10.14814/phy2.70844

PMCPMC13140577

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.