Evidence map›Paper›PMID 41906329›Full record

SynthesisJournal of the science of food and agriculture2026

Biological activities and bioactive constituents of Flammulina velutipes: An updated systematic review.

Rıdvan Özgen, Didem Şöhretoğlu, Ayşe Kuruüzüm-Uz

Abstract readSystematic ReviewReview
PubMed Publisher
In one paragraph

Synthesis in Journal of the science of food and agriculture, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Rıdvan ÖzgenDepartment of Pharmaceutical Botany, Faculty of Pharmacy, Inonu University, Malatya, Turkey.ORCID https://orcid.org/0000-0002-2505-027X
Didem ŞöhretoğluDepartment of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, Sıhhiye/Ankara, Turkey.ORCID https://orcid.org/0000-0002-8264-5544
Ayşe Kuruüzüm-UzDepartment of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, Sıhhiye/Ankara, Turkey.ORCID https://orcid.org/0000-0003-3373-4759

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Flammulina velutipes (enokitake) is an edible mushroom recognized for both its nutritional and medicinal properties. It exhibits a broad spectrum of biological activities, including antioxidant, anti-inflammatory, antitumor, immunomodulatory, and gut microbiota-regulating effects. These effects are primarily attributed to bioactive compounds such as polysaccharides, phenolic compounds, and sterols, and are mediated through the modulation of multiple signaling pathways, including NF-κB, MAPK, and PI3K/Akt. Collectively, the available evidence indicates that F. velutipes represents a promising candidate for the development of functional foods and pharmaceutical formulations. This review emphasizes its therapeutic potential and provides valuable insights to guide future medicinal research. © 2026 The Author(s). Journal of the Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

Indexed as

FlammulinaPlant ExtractsAnimalsAnti-Inflammatory AgentsAntineoplastic AgentsAntioxidantsHumansNF-kappa BPhenolsPolysaccharidesSignal TransductionAnti-Inflammatory AgentsAntineoplastic AgentsAntioxidantsNF-kappa BPhenolsPlant ExtractsPolysaccharidesenokienokitakeFlammulina velutipesfunctional foodspolysaccharides

Identifiers

PMID41906329

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.