Evidence map›Paper›PMID 41906286›Full record

ArticleACS chemical biology2026

Investigating Opioid Receptor Activity through Biocatalytic Halogenation and Oxidation of Mitragynine.

Natalia R Harris, Alexander J Powell, Harrison M Snodgrass, Sahar Amin, Sean A Newmister, Brian J Curtis, Danny Li, Zehra A Husaini, Linnea Verhey-Henke, Janet L Smith and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Natalia R HarrisLife Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.
Alexander J PowellDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States.ORCID 0009-0009-8076-0563
Harrison M SnodgrassDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.
Sahar AminLife Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.
Sean A NewmisterLife Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.
Brian J CurtisLife Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.
Danny LiLife Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.
Zehra A HusainiLife Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.
Linnea Verhey-HenkeLife Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.
Janet L SmithLife Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID 0000-0002-0664-9228
Filipa PereiraLife Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.
Jared C LewisDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.ORCID 0000-0003-2800-8330
John TraynorDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States.
David H ShermanLife Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID 0000-0001-8334-3647

Funding

Interdepartmental Training in Pharmacological SciencesT32GM140223 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lori L. Isom · 2021 to 2026
$3.8M
Discovery and Characterization of Natural Product Systems-Research Supplement to Promote DiversityR35GM118101 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHERMAN, DAVID H · 2016 to 2025
$3.3M
Engineering Halogenases for Small Molecule Functionalization and Enantioselective CatalysisR35GM152068 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI JARED C LEWIS · 2024 to 2026
$1.2M
Structural Biology of Complex EnzymesR01GM161002 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SMITH, JANET L. · 2025 to 2025
$785k
Recovery is Achievable: Biocatalytic approaches to Diversifying Mitragynine Analogs for Opioid Substitution TherapiesF31DA055451 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HARRIS, NATALIA · 2022 to 2025
$137k
NIDA NIH HHS F31 DA055451NIGMS NIH HHS R01 GM161002NIGMS NIH HHS R35 GM118101NIGMS NIH HHS R35 GM152068NIGMS NIH HHS T32 GM140223
6 · The paper itself

Abstract

The development of safer opioid therapeutics remains an urgent challenge, given the limitations and adverse effects of current μ-opioid receptor (MOR) agonists. Natural products such as mitragynine, the predominant alkaloid from

Indexed as

Receptors, Opioid, muSecologanin Tryptamine AlkaloidsBiocatalysisEscherichia coliHalogenationOxidation-ReductionmitragynineReceptors, Opioid, muSecologanin Tryptamine Alkaloids

Identifiers

PMID41906286
PMCPMC13060569

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.