ArticlePest management science2026
Non-triazine photosystem II inhibitors provide effective control of metabolic atrazine-resistant Amaranthus tuberculatus.
Article in Pest management science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundOverexpression of the Phi-class glutathione S-transferase (GST) AtuGSTF2 has been implicated in the detoxification of atrazine in Amaranthus tuberculatus (Moq.) Sauer (waterhemp). However, little is known about this GST and the susceptibility of resistant populations to other Photosystem II (PSII)-inhibitors remains unclear. Therefore, this study evaluated the efficacy of non-triazine PSII-inhibitors amicarbazone and metribuzin against atrazine-resistant A. tuberculatus. Molecular docking analysis with these molecules was also conducted at the PSII target-site to further investigate differences in their relative potencies and recommended field-use rates. Furthermore, the AtuGSTF2 gene and translated protein structure were analyzed to identify potential regulatory relationships and characterize the active site.
resultsCompared to atrazine, amicarbazone improved the control of metabolic atrazine resistant populations to a greater extent than metribuzin, and control was further improved when amicarbazone and metribuzin were applied in a 1.75:1 mixture. Molecular docking indicated that amicarbazone interacts with the target site similarly to atrazine and metribuzin but with greater predicted affinity. Genomic and structural analyses suggest that AtuGSTF2 may be regulated by multiple transcription factors and the encoded protein exhibits substrate recognition promiscuity consistent with other GSTs.
conclusionTogether, these findings indicate that amicarbazone is a potent molecule and offers a more effective alternative to atrazine than metribuzin for managing at least some NTS atrazine-resistant A. tuberculatus populations. However, tank-mixing amicarbazone with metribuzin can provide even more effective control than either herbicide alone. Furthermore, substrate recognition promiscuity could possibly endow AtuGSTF2 with the potential for broader metabolic cross-resistance. © 2026 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
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