ArticleWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
Autologous Blood Clot Therapy for Wounds: Investigating the Chemotactic Effect on PBMCs and Fibroblasts in Diabetes.
Article in Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Topically applied autologous blood clot therapy (TABCT) is a low-cost regenerative modality proposed for complex wounds, yet its biological mechanism of action remains poorly defined. We investigated whether factors released from autologous blood clots promote peripheral blood mononuclear cell (PBMC) chemotaxis and fibroblast migration, and whether these effects are altered in individuals with metabolic syndrome/type 2 diabetes (MetS/DM). Twenty-two participants (controls n = 12; MetS/DM n = 10) were recruited. Autologous clots were generated ex vivo, cultured for 24 h, and the secretome analysed for total protein, PDGF-BB, P-selectin and CCL-5. PBMC basal activation (ROS production, phagocytosis, migration, Ca
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