APP family in inhibitory neurons controls inhibitory recruitment and short-term plasticity in the hippocampus.

Sang Hun Lee, Jongkyun Kang, Chen Zhang, Vadim Y Bolshakov, Jie Shen

Abstract read

In one paragraph

Article in Molecular brain, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sang Hun LeeDepartment of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. slee82@bwh.harvard.edu.

Jongkyun KangDepartment of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.

Chen ZhangDepartment of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.

Vadim Y BolshakovDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, 02478, USA.

Jie ShenDepartment of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.

Funding

Role of Presenilins in the SynapseR01NS041783 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI Jie Shen · 2001 to 2026

$10.6M

NINDS NIH HHS R01 NS041783NINDS NIH HHS R01NS041783

6 · The paper itself

Abstract

Amyloid precursor protein (APP) is associated with both familial and sporadic forms of Alzheimer's disease. We previously reported that APP and its family members, amyloid precursor-like proteins 1 and 2 (APLP1 and APLP2), regulate intrinsic neuronal excitability and synaptic plasticity in excitatory principal neurons, though APP family is dispensable for neuronal survival. However, the physiological role of APP family in inhibitory interneurons remains poorly understood. Here, we use our previously characterized floxed APP, APLP1, APLP2 and GAD2-Cre alleles to generate inhibitory neuron-specific conditional triple knockout (IN-APP/APLP1/APLP2 cTKO) mice. Our electrophysiological analysis of acute hippocampal slices revealed that IN-APP/APLP1/APLP2 cTKO CA1 pyramidal neurons exhibit increased amplitudes of evoked GABA

Indexed as

Amyloid beta-Protein PrecursorHippocampusNeural InhibitionNeuronal PlasticityNeuronsAnimalsCA1 Region, HippocampalExcitatory Postsynaptic PotentialsInhibitory Postsynaptic PotentialsInterneuronsLong-Term PotentiationMice, KnockoutPyramidal CellsSchaffer CollateralsSynapsesAmyloid beta-Protein PrecursorAplp1 protein, mouseAplp2 protein, mouseAlzheimer’s diseaseAmyloid Precursor ProteinConditional triple knockoutHippocampusInhibitory neuronLong-term potentiationSchaffer collateralShort-term synaptic plasticity

Identifiers

PMID41906151

DOI10.1186/s13041-026-01296-0

PMCPMC13151265

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.