Evidence map›Paper›PMID 41906122›Full record

ArticleParasites & vectors2026

First record of Phlebotomus (Larroussius) orientalis (Parrot, 1936) (Diptera: Psychodidae) in Israel: phylogeographic placement and implications for leishmaniasis surveillance.

Debora Diaz, Edwin Kniha, Stephan Koblmüller, Liora Studentsky, Shirly Lea Elbaz, Ira Ben Avi, Simcha Shilo, Shira Kalmus, Fouad Akad, Itay Naveh and 4 more

Abstract read
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Article in Parasites & vectors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Debora Diaz *Public Health Laboratories, Jerusalem (PHL-J), Public Health Services (PHS), Ministry of Health (MOH), Jerusalem, Israel.
Edwin Kniha *Institute of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Stephan KoblmüllerInstitute of Biology, University of Graz, Graz, Austria.
Liora StudentskyPublic Health Laboratories, Jerusalem (PHL-J), Public Health Services (PHS), Ministry of Health (MOH), Jerusalem, Israel.
Shirly Lea ElbazPublic Health Laboratories, Jerusalem (PHL-J), Public Health Services (PHS), Ministry of Health (MOH), Jerusalem, Israel.
Ira Ben AviPublic Health Laboratories, Jerusalem (PHL-J), Public Health Services (PHS), Ministry of Health (MOH), Jerusalem, Israel.
Simcha ShiloPublic Health Laboratories, Jerusalem (PHL-J), Public Health Services (PHS), Ministry of Health (MOH), Jerusalem, Israel.
Shira KalmusPublic Health Laboratories, Jerusalem (PHL-J), Public Health Services (PHS), Ministry of Health (MOH), Jerusalem, Israel.
Fouad AkadPublic Health Laboratories, Tel Aviv, Public Health Services, Ministry of Health (MOH), Tel Aviv, Israel.
Itay NavehNature and Parks Authority, Jerusalem, Israel.
Shay ReicherDivision of Pest Control and Pesticides, Ministry of Environmental Protection, Jerusalem, Israel.
Maya Davidovich-CohenPublic Health Laboratories, Jerusalem (PHL-J), Public Health Services (PHS), Ministry of Health (MOH), Jerusalem, Israel.
Laor OrshanPublic Health Laboratories, Jerusalem (PHL-J), Public Health Services (PHS), Ministry of Health (MOH), Jerusalem, Israel.
Oscar David KirsteinPublic Health Laboratories, Jerusalem (PHL-J), Public Health Services (PHS), Ministry of Health (MOH), Jerusalem, Israel. oscar.kirstein@moh.gov.il.

Funding

HORIZON EUROPE Framework Programme 101057690UK Research and Innovation 10038150
6 · The paper itself

Abstract

backgroundPhlebotomine sand flies (Diptera: Psychodidae) are the principal vectors of Leishmania spp., the causative agents of leishmaniasis. Since 2008, the Ministry of Health and the Ministry of Environmental Protection of Israel have conducted nationwide, periodic sand fly surveys. Initially, these surveys focused on localities with known endemic transmission of cutaneous leishmaniasis, but in recent years, entomological trapping has expanded to areas where prior information on sand flies was unavailable. Here we report the first confirmed occurrence of Phlebotomus (Larroussius) orientalis (Parrot, 1936) in Israel and place the Israeli material in a comparative phylogeographic context.

methodsEntomological surveys by CO

resultsTargeted surveys and routine surveillance in the Negev region between 2020 and 2024 yielded 269 Phlebotomus orientalis (96 males, 173 females) among other species of local sand fly fauna from multiple wadi systems in the central Negev. These detections constitute the first confirmed records of Ph. orientalis in Israel. Species identification was confirmed through both morphological examination and molecular analyses of partial COI and Cytb/NADH1 genes. Phylogenetic analysis indicated that the Israeli Ph. orientalis specimens constitute a distinct lineage that diverged from East African conspecifics during the Early to Middle Pleistocene. Blood-meal analysis of engorged Ph. orientalis females identified the European hare as a vertebrate host, and none of the tested Ph. orientalis specimens were positive for Leishmania DNA.

conclusionsPhlebotomus orientalis is a confirmed vector of L. donovani, the main agent of visceral leishmaniasis in East Africa. Its detection as a distinct and apparently long-established lineage in the Negev, in a region where parasites of the L. donovani complex are already involved in cutaneous leishmaniasis transmission, highlights the need to clarify the distribution, ecology, and host preferences of Ph. orientalis in Israel. Further studies are required to characterize its spatial and seasonal occurrence, evaluate its vector competence for L. donovani and L. infantum, and assess its potential contribution to current and future leishmaniasis transmission risks.

Indexed as

Insect VectorsLeishmaniasisPhlebotomusAnimalsFemaleIsraelLeishmaniaMalePhylogenyPhylogeographyBarcodingDivergence time estimatesHaplotypingLeishmaniasisNegev DesertPhlebotomus orientalisSand flies

Identifiers

PMID41906122
PMCPMC13154854

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.