Evidence map›Paper›PMID 41906064›Full record

ReviewJournal of natural medicines2026

Recent advances in progress of natural anticoagulant active substances.

Meilian Zhong, Xiao Liu, Juting Liao, Yang Zhang, Youbin Li, Shuojin Wang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of natural medicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Meilian ZhongHainan Provincial Key Laboratory for Research and Development of Tropical Herbs, Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Pharmacy, Hainan Medical University, XueYuan Road No. 3, LongHua District, Haikou City, 571199, Hainan Province, China.
Xiao LiuHainan Provincial Key Laboratory for Research and Development of Tropical Herbs, Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Pharmacy, Hainan Medical University, XueYuan Road No. 3, LongHua District, Haikou City, 571199, Hainan Province, China.
Juting LiaoHainan Provincial Key Laboratory for Research and Development of Tropical Herbs, Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Pharmacy, Hainan Medical University, XueYuan Road No. 3, LongHua District, Haikou City, 571199, Hainan Province, China.
Yang ZhangHainan Provincial Key Laboratory for Research and Development of Tropical Herbs, Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Pharmacy, Hainan Medical University, XueYuan Road No. 3, LongHua District, Haikou City, 571199, Hainan Province, China.
Youbin LiHainan Provincial Key Laboratory for Research and Development of Tropical Herbs, Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Pharmacy, Hainan Medical University, XueYuan Road No. 3, LongHua District, Haikou City, 571199, Hainan Province, China. 1365260199@qq.com.
Shuojin WangHainan Provincial Key Laboratory for Research and Development of Tropical Herbs, Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Pharmacy, Hainan Medical University, XueYuan Road No. 3, LongHua District, Haikou City, 571199, Hainan Province, China. wang.shuojin@muhn.edu.cn.ORCID http://orcid.org/0000-0003-0715-6297

Funding

Academic Enhancement Support Program of Hainan Medical University XSTS2025182Hainan Provincial Natural Science Foundation of China No. 20152023Hainan Provincial Natural Science Foundation of China No. 2019RC229
6 · The paper itself

Abstract

Thrombotic diseases pose a serious threat to human life and health. Anticoagulant drugs are used to treat and prevent thrombotic diseases. However, although the anticoagulant drugs currently used in clinical practice are effective, they have limitations such as narrow therapeutic window and high risk of bleeding. Therefore, the development of new safe and effective anticoagulants based on natural products and their structural modifications has become an important research direction to overcome the current treatment bottlenecks in this field. In this paper, "thrombotic diseases", "anticoagulant-active molecules", "natural products" and "structural modifications" were used as keywords to search the research data on anticoagulant-active molecules published in the past decade in PubMed, Web of Science, ScienceDirect, Google Scholar and CNKI databases. The research progress of anticoagulant- active molecules from animals and plants was reviewed, which provide basic data for promoting the development of innovative anticoagulant drugs. In this paper, the classification of thrombotic diseases and the clinical drugs currently used in clinical practice are reviewed. Next, the coagulation mechanism and the fact that an imbalance between coagulation and anticoagulation in vivo can lead to thrombosis are described. Finally, the research reports on anticoagulant active compounds and their structural modifications from plants and animals in the past 10 years are summarized. A total of 68 anticoagulant molecules were identified, which provide an important direction and candidate molecules for the development of new, efficient and low-risk anticoagulant drugs.

Indexed as

AnticoagulantsBiological ProductsThrombosisAnimalsBlood CoagulationHumansAnticoagulantsBiological ProductsAnticoagulant-active moleculesNatural productsStructural modificationsThrombotic diseases

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.