ArticleTherapeutic advances in respiratory disease
Discriminating nodular pulmonary alveolar proteinosis from lung adenocarcinoma with radiomic model and multimodal model.
Article in Therapeutic advances in respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPulmonary alveolar proteinosis (PAP) typically manifests as diffuse lung disease, while nodular PAP presenting as pulmonary nodules is extremely rare and often radiologically indistinguishable from early-stage lung adenocarcinoma (LUAD).
objectivesThis study aims to establish an accurate diagnostic algorithm to prevent unnecessary invasive procedures in patients with nodular PAP.
designThis study was a retrospective, single-center study.
methodsThis study enrolled 16 pathologically confirmed nodular PAP patients and 52 early-stage LUAD patients, systematically comparing their clinical characteristics and biochemical markers. A radiomics model was developed based on CT imaging features, followed by a multimodal model incorporating significant clinical and biochemical discriminators.
resultsThe nodular PAP cohort demonstrated a 3:5 male-to-female ratio, equivalent distribution of solitary versus multiple nodules, and nodule diameters spanning 3-28 mm. Nodular PAP patients were significantly younger (mean 51.4 vs 67.0 years,
conclusionThis study provides the characterization of nodular PAP and establishes radiomic and multimodal diagnostic models with similar accuracy, which are reliable tools to make a differential diagnosis between nodular PAP and LUAD and to prevent unnecessary surgery.
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