Evidence map›Paper›PMID 41905745›Full record

ArticleBMJ open2026

Influence of lifestyle factors on breast cancer incidence from mid-life to older age: an Australian longitudinal cohort study.

Md Sohel Rana, M Luke Marinovich, Nehmat Houssami, Dominic Cavenagh, Julie E Byles, Md Mijanur Rahman, Xue Qin Yu

Abstract read
In one paragraph

Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Md Sohel RanaThe Daffodil Centre, The University of Sydney and Cancer Council NSW, Sydney, New South Wales, Australia mran9130@uni.sydney.edu.au.ORCID http://orcid.org/0000-0003-3749-6807
M Luke MarinovichThe Daffodil Centre, The University of Sydney and Cancer Council NSW, Sydney, New South Wales, Australia.
Nehmat HoussamiThe Daffodil Centre, The University of Sydney and Cancer Council NSW, Sydney, New South Wales, Australia.
Dominic CavenaghCentre for Women's Health Research, University of Newcastle, Newcastle, New South Wales, Australia.
Julie E BylesHunter Medical Research Institute, New Lambton Heights, New South Wales, Australia.
Md Mijanur Rahman *The Daffodil Centre, The University of Sydney and Cancer Council NSW, Sydney, New South Wales, Australia.
Xue Qin Yu *The Daffodil Centre, The University of Sydney and Cancer Council NSW, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0001-8638-7979

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThere is limited evidence on the association between lifestyle factors and breast cancer (BC) incidence from Australian longitudinal studies. This study aims to investigate the influence of lifestyle factors on BC incidence over time among Australian women from mid-life to older age.

designLongitudinal study.

settingData from the Australian Longitudinal Study on Women's Health (ALSWH) and linked Australian Cancer Database (ACD).

participants12 782 women from the ALSWH 1946-1951 birth cohort linked with the ACD from 1996 to 2019. MAIN OUTCOME AND MEASURES: Time to the occurrence of BC, accounting for death as a competing event. Body mass index, alcohol consumption, smoking, marital status, oral contraception and hormone replacement therapy were considered as lifestyle factors due to their impact from mid-life to older age.

resultsAmong 12 782 women in the cohort, a total of 941 incident BC cases (7.4%) were identified between 1996 and 2019. Time-dependent analysis disclosed that a higher hazard of BC in alcohol drinkers (rarely drinks/low-risk drinkers: Subdistribution HR [sHR]=1.49, 95% CI: 1.33-1.69; risky/high-risk drinkers: sHR=1.36, 95% CI: 1.14-1.62) relative to non-drinkers and those with overweight/obesity (sHR=1.23, 95% CI: 1.14-1.32) relative to underweight/acceptable weight. Results also revealed that non-partnered women (sHR=1.32, 95% CI: 1.12-1.57) had a higher hazard of BC than those with partners. Models were adjusted for lifestyle, reproductive and demographic factors. The probability of cumulative incidence of BC for alcohol drinkers and overweight/obese women steadily increased over time.

conclusionThis study demonstrated that being non-partnered, overweight/obese and consuming alcohol were associated with increased hazards of BC in women's mid-life to older age.

Indexed as

Breast NeoplasmsLife StyleAdultAgedAlcohol DrinkingAustraliaBody Mass IndexFemaleHumansIncidenceLongitudinal StudiesMiddle AgedRisk FactorsSmokingBreast tumoursEpidemiologyLongitudinal studiesONCOLOGYPUBLIC HEALTH

Identifiers

PMID41905745
PMCPMC13034360

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.