Evidence map›Paper›PMID 41905556›Full record

ArticleThe Journal of molecular diagnostics : JMD2026

Diagnostic Utility of Single Nucleotide Polymorphism Microarray in Evaluating Pancreaticobiliary Brushing Specimens in Conjunction with Conventional Cytology.

Ahmet Alptekin, Ashis K Mondal, Ashutosh Vashisht, Vishakha Vashisht, Harmanpreet Singh, Daley Morera, Pankaj Ahluwalia, Jaspreet Farmaha, Sravankumar Kavuri, Nikhil Patel and 4 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of molecular diagnostics : JMD, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ahmet AlptekinDepartment of Pathology, Medical College of Georgia, Augusta, Georgia.
Ashis K MondalDepartment of Pathology, Medical College of Georgia, Augusta, Georgia.
Ashutosh VashishtDepartment of Pathology, Medical College of Georgia, Augusta, Georgia.
Vishakha VashishtDepartment of Pathology, Medical College of Georgia, Augusta, Georgia.
Harmanpreet SinghDepartment of Pathology, Medical College of Georgia, Augusta, Georgia.
Daley MoreraDepartment of Pathology, Medical College of Georgia, Augusta, Georgia.
Pankaj AhluwaliaDepartment of Pathology, Medical College of Georgia, Augusta, Georgia.
Jaspreet FarmahaDepartment of Pathology, Medical College of Georgia, Augusta, Georgia.
Sravankumar KavuriDepartment of Pathology, Medical College of Georgia, Augusta, Georgia.
Nikhil PatelDepartment of Pathology, Medical College of Georgia, Augusta, Georgia.
Luis A Velasquez ZarateDepartment of Pathology, Medical College of Georgia, Augusta, Georgia.
Subbaramiah SridharDepartment of Gastroenterology and Hepatology, Augusta University, Augusta, Georgia.
Viveksandeep T ChandrasekarDepartment of Gastroenterology and Hepatology, Augusta University, Augusta, Georgia.
Ravindra KolheDepartment of Pathology, Medical College of Georgia, Augusta, Georgia. Electronic address: rkolhe@augusta.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bile duct brushings are noninvasive samplings of cells from the biliary tract for cytologic evaluation and are useful to diagnose pancreaticobiliary malignancies. Although specificity of cytology is satisfactory, sensitivity is inherently low because of challenging or absent morphologic features. Using molecular markers by incorporating fluorescence in situ hybridization has significantly improved sensitivity and diagnosis. To further advance the use of molecular markers, OncoScan microarray was used, which has genome-wide coverage and significantly higher resolution compared with fluorescence in situ hybridization. This study tested 128 pancreaticobiliary brushing specimens with OncoScan and compared them with cytology while using the biopsy of these patients as a reference. OncoScan was able to detect more malignant cases compared with cytology. In addition, the study identified potential molecular markers that have not been previously studied or reported. This study demonstrates that OncoScan is a useful additional diagnostic tool with cytology for pancreaticobiliary brushing specimens by improving the sensitivity to detect malignancies.

Indexed as

Bile Duct NeoplasmsPancreatic NeoplasmsPolymorphism, Single NucleotideAdultAgedBile DuctsBiomarkers, TumorFemaleHumansIn Situ Hybridization, FluorescenceMaleMiddle AgedOligonucleotide Array Sequence AnalysisSensitivity and SpecificityBiomarkers, Tumor

Identifiers

PMID41905556
PMCPMC13269343

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.