Evidence map›Paper›PMID 41905514›Full record

ArticleThe Journal of investigative dermatology2026

Endothelial cell expression of STING

Jane Chuprin, Carolina Salomāo Lopes, Kevin MingJie Gao, Kristy Chiang, Khashayar Afshari, Nazgol Haddadi, Mridushi Daga, Olivia Dekker, Manuel Garber, Milka Koupenova and 3 more

Abstract read
In one paragraph

Article in The Journal of investigative dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Jane ChuprinDepartment of Dermatology, UMass Chan Medical School, Worcester, Massachusetts, USA.
Carolina Salomāo LopesDepartment of Genomics and Computational Biology, UMass Chan Medical School, Worcester, Massachusetts, USA.
Kevin MingJie GaoDepartment of Medicine, UMass Chan Medical School, Worcester, Massachusetts, USA.
Kristy ChiangDepartment of Medicine, UMass Chan Medical School, Worcester, Massachusetts, USA.
Khashayar AfshariDepartment of Dermatology, UMass Chan Medical School, Worcester, Massachusetts, USA.
Nazgol HaddadiDepartment of Dermatology, UMass Chan Medical School, Worcester, Massachusetts, USA.
Mridushi DagaDepartment of Medicine, UMass Chan Medical School, Worcester, Massachusetts, USA.
Olivia DekkerDepartment of Medicine, UMass Chan Medical School, Worcester, Massachusetts, USA.
Manuel GarberDepartment of Genomics and Computational Biology, UMass Chan Medical School, Worcester, Massachusetts, USA.
Milka KoupenovaDepartment of Medicine, UMass Chan Medical School, Worcester, Massachusetts, USA.
Katherine A FitzgeraldDepartment of Medicine, UMass Chan Medical School, Worcester, Massachusetts, USA.
Ann Marshak-RothsteinDepartment of Medicine, UMass Chan Medical School, Worcester, Massachusetts, USA. Electronic address: ann.rothstein@umassmed.edu.
Mehdi RashighiDepartment of Dermatology, UMass Chan Medical School, Worcester, Massachusetts, USA. Electronic address: mehdi.rashighi@umassmed.edu.

Funding

Medical Scientist Training at UMMS Administrative SupplementT32GM107000 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KIEFE, CATARINA I. · 2013 to 2022
$4.9M
Mechanisms of STING-driven autoinflammationR01HL165787 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Katherine A. Fitzgerald, Ann Marshak-Rothstein · 2023 to 2026
$3.3M
The role of TLRs, Type II IFN and Type III IFN in a Murine Model of AutoinflammationR37AI155901 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Ann Marshak-Rothstein · 2021 to 2026
$3.1M
Mechanisms of platelet reprogramming during influenza infectionR01HL153235 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KOUPENOVA, MILKA · 2020 to 2024
$2.1M
Training in the Molecular Basis of Autoimmunity and AutoinflammationT32AI132152 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Katherine A. Fitzgerald, Ann Marshak-Rothstein · 2018 to 2026
$1.6M
Radioresistant Innate Immunity in SAVI Tissue-Specific AutoinflammationR21AI178978 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FITZGERALD, KATHERINE A., MARSHAK-ROTHSTEIN, ANN · 2023 to 2024
$461k
Platelet-MLKL role in S100 Release with Age and InfectionR21AG093333 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KOUPENOVA, MILKA · 2025 to 2025
$461k
NHLBI NIH HHS R01 HL153235NHLBI NIH HHS R01 HL165787NIAID NIH HHS R21 AI178978NIAID NIH HHS R37 AI155901NIAID NIH HHS T32 AI132152NIA NIH HHS R21 AG093333NIGMS NIH HHS T32 GM107000
6 · The paper itself

Abstract

Gain-of-function mutations in STING (STimulator of IFN Genes) cause STING-associated vasculopathy with onset in infancy (SAVI), a rare autoinflammatory disease characterized by debilitating inflammatory lung disease and hallmark skin manifestations, such as chilblains and progressive, nonhealing ulcers. Mice expressing the most common SAVI-associated variant, STING

Indexed as

Endothelial CellsGain of Function MutationMembrane ProteinsSkinUltraviolet RaysAnimalsDisease Models, AnimalHumansMiceSTING ProteinMembrane ProteinsSting1 protein, mouseSTING ProteinEndothelial cellsInflammationSAVISTINGUVB injury

Identifiers

PMID41905514
PMCPMC13386398

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.