Evidence map›Paper›PMID 41905068›Full record

ArticlePoultry science2026

Investigation of the effects and underlying mechanisms of adenylate kinase 1 on inosine monophosphate deposition in Beijing-You chickens.

Jingyan Hou, Yao Zhang, Liyang Zhu, Xiaolong Qi, Xiangguo Wang, Zili Lin, Longfei Xiao, Cheng Long, Jinhuan Dou, Yaxi Xu and 1 more

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Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Jingyan HouAnimal Science and Technology College, Beijing University of Agriculture, Beijing, 102206, China.
Yao ZhangAnimal Science and Technology College, Beijing University of Agriculture, Beijing, 102206, China.
Liyang ZhuAnimal Science and Technology College, Beijing University of Agriculture, Beijing, 102206, China.
Xiaolong QiAnimal Science and Technology College, Beijing University of Agriculture, Beijing, 102206, China.
Xiangguo WangAnimal Science and Technology College, Beijing University of Agriculture, Beijing, 102206, China.
Zili LinAnimal Science and Technology College, Beijing University of Agriculture, Beijing, 102206, China.
Longfei XiaoAnimal Science and Technology College, Beijing University of Agriculture, Beijing, 102206, China.
Cheng LongAnimal Science and Technology College, Beijing University of Agriculture, Beijing, 102206, China.
Jinhuan DouAnimal Science and Technology College, Beijing University of Agriculture, Beijing, 102206, China.
Yaxi XuAnimal Science and Technology College, Beijing University of Agriculture, Beijing, 102206, China.
Xihui ShengAnimal Science and Technology College, Beijing University of Agriculture, Beijing, 102206, China. Electronic address: shengxh03@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inosine monophosphate (IMP) is a major flavor compound in meat. Given the observed positive correlation between adenylate kinase 1 (AK1) expression and IMP content in Beijing-You chickens (BJYs), we investigated the role of AK1 in regulating myoblast proliferation and differentiation. Cell counting kit-8 (CCK-8) assays, 5-ethynyl-2'-deoxyuridine (EdU) incorporation, flow cytometry, and Western blotting showed that AK1 promoted myogenic differentiation and suppressed the proliferative activity of myoblasts. During the proliferation of myoblasts, glutamine phosphoribosylpyrophosphate amidotransferase (GPAT) was suppressed by AK1 and adenylosuccinate synthase (ADSS) was enhanced, which led to reduced IMP accumulation and inhibited uric acid (UA) and adenosine triphosphate (ATP) production. During myoblast differentiation, the protein expression of de novo IMP synthesis genes, including GPAT, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (PurH), and adenylosuccinate lyase (ADSL), was upregulated, while ADSS was downregulated by AK1, resulting in enhanced IMP deposition and stimulated production of UA and ATP. In summary, this study elucidates the regulatory role of AK1 in coordinating the proliferation and differentiation of myoblasts, as well as its stage-specific modulation of IMP anabolism. These findings provide theoretical insights into the molecular mechanisms governing IMP deposition and offer potential guidance for improving meat flavor quality in chicken through molecular breeding strategies.

Indexed as

Adenylate KinaseAvian ProteinsChickensInosine MonophosphateMyoblastsAnimalsCell DifferentiationCell ProliferationAdenylate Kinaseadenylate kinase 1Avian ProteinsInosine MonophosphateAdenylate kinase 1Beijing-You chickenInosine monophosphateMeat qualityMyoblast

Identifiers

PMID41905068
PMCPMC13049296

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.