ArticlePoultry science2026
Integrated transcriptomic and metabolomic analysis identifies C5NT1AL as a candidate gene influencing inosine monophosphate levels in chicken breast muscle.
Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inosine monophosphate (IMP) is a key umami-related nucleotide that contributes substantially to chicken meat flavor. This study aimed to elucidate the molecular regulatory mechanisms underlying individual variation in breast muscle IMP content in Beijing-You chicken through integrative transcriptomic and metabolomic analysis. A total of 73 male Beijing-You chickens at 135 days of age were phenotyped for IMP content in breast muscle. For extreme phenotype comparisons, 10 individuals with the highest IMP contents and 10 individuals with the lowest IMP contents were defined as the high-IMP and low-IMP groups, respectively. Transcriptomic and metabolomic datasets were generated from all 73 samples, and integrated using correlation analysis, Weighted Gene Co-expression Network Analysis (WGCNA), and machine learning models. Whereas extreme-group comparisons were used for PCA, differential analysis. IMP content showed moderate phenotypic variability within the population. Transcriptome analysis integrating elastic net regression, support vector machine (SVM) modeling, and differential expression analysis identified 22 high-confidence genes associated with IMP content, which were significantly enriched in various pathways, including purine metabolism, pyrimidine metabolism, and nicotinate and nicotinamide metabolism. Metabolomic integration combining WGCNA, differential analysis, and correlation analysis identified 14 key metabolites negatively correlated with IMP content, primarily enriched in purine metabolism, nucleotide metabolism, and the ABC transporter pathway. Integrated multi-omics analysis highlighted cytosolic 5'-nucleotidase 1A-like (C5NT1AL), which was co-enriched with inosine, hypoxanthine, and guanosine within the purine metabolism pathway. These results suggest that C5NT1AL potentially regulates IMP deposition in chicken breast muscle through regulation of IMP dephosphorylation and downstream purine metabolic flux. This study identified C5NT1AL as a promising candidate gene influencing umami-related nucleotide metabolism and provides molecular insight into the genetic improvement of chicken meat flavor quality.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.