ReviewThe Journal of international medical research2026
Clinical applications of esketamine: Current status and future perspectives.
Review in The Journal of international medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Peripartum Esketamine: A Narrative Review of Analgesia, Postpartum Depressive Symptoms, Sleep-Related Outcomes, and Safety.Drug design, development and therapy · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ketamine, a dissociative anesthetic, has been extensively used in clinical anesthesia and sedation. However, its use in general anesthesia is gradually declining because of numerous adverse effects. In 2019, esketamine was introduced to the Chinese market. This narrative review aimed to summarize the current status of clinical applications and research progress of esketamine and to explore its future prospects in clinical practice. The scope of this review covered the pharmacological properties of esketamine; its clinical applications in surgical anesthesia, perioperative analgesia, painless diagnosis and treatment, intensive care, emergency care, and special populations (pediatric and obstetric patients); and its organ-protective effects and application value in the treatment of mental disorders. In addition, the adverse effects of esketamine have been summarized to provide a comprehensive reference for its rational clinical use. This study searched core databases, including PubMed, Embase, the Cochrane Library, and Web of Science. The search terms included esketamine, S-ketamine, anesthesia, analgesia, and depression, using a combined logical search of subject terms and free terms. The search period spanned from the establishment of each database through June 2025. Esketamine has since gained increasing popularity for surgical anesthesia, analgesia, and pain management because of its potent analgesic and anesthetic properties. Esketamine is important not only for anesthesia and analgesia in surgical patients during the perioperative period but also for broader applications in intensive care and emergency care, particularly in the treatment of mental illness. Therefore, Esketamine offers a broader and safer application prospect in surgical anesthesia, perioperative pain management, medication for special populations, and psychiatric disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.