Evidence map›Paper›PMID 41904948›Full record

ArticleCell reports2026

Sexual dimorphism shapes renal metabolic adaptation to a ketogenic diet.

Miranda E Kelly, Lauren A Hoffner, Cuauhtemoc B Ramirez, Alexis L Anica, Joohwan Kim, Gregory Tong, Yeojin Kim, Vyshnavi Mannepalli, Wonsuk Choi, Ki-Hong Jang and 15 more

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Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Miranda E KellyDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Irvine, CA 92697-4025, USA.
Lauren A HoffnerDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Irvine, CA 92697-4025, USA.
Cuauhtemoc B RamirezDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Irvine, CA 92697-4025, USA; Department of Microbiology and Molecular Genetics, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Irvine, CA 92697-4025, USA.
Alexis L AnicaDepartment of Microbiology and Molecular Genetics, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Irvine, CA 92697-4025, USA.
Joohwan KimDepartment of Microbiology and Molecular Genetics, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Irvine, CA 92697-4025, USA.
Gregory TongDepartment of Pharmaceutical Sciences, Chao Family Comprehensive Cancer Center, University of California Irvine School of Pharmacy and Pharmaceutical Sciences, Irvine, CA 92697-4025, USA.
Yeojin KimDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Irvine, CA 92697-4025, USA.
Vyshnavi MannepalliDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Irvine, CA 92697-4025, USA.
Wonsuk ChoiDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Irvine, CA 92697-4025, USA.
Ki-Hong JangDepartment of Microbiology and Molecular Genetics, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Irvine, CA 92697-4025, USA.
Yasmine H AlamDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Irvine, CA 92697-4025, USA.
Sunhee JungDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Irvine, CA 92697-4025, USA.
Johnny LeDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Irvine, CA 92697-4025, USA.
Miranda L LopezDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Irvine, CA 92697-4025, USA.
Varvara I RubtsovaDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Irvine, CA 92697-4025, USA; Department of Microbiology and Molecular Genetics, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Irvine, CA 92697-4025, USA.
Hosung BaeDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Irvine, CA 92697-4025, USA.
Yujin ChunDepartment of Microbiology and Molecular Genetics, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Irvine, CA 92697-4025, USA.
Won-Suk SongDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Irvine, CA 92697-4025, USA.
Ian J TamburiniDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Irvine, CA 92697-4025, USA.
Victor L SchusterDepartment of Internal Medicine, Albert Einstein College of Medicine, Bronx, New York, NY, USA.
Hoda Anton-CulverDepartment of Medicine, University of California Irvine School of Medicine, Irvine, CA 92697-4025, USA.
Wei Ling LauDivision of Nephrology, University of California Irvine School of Medicine, Irvine, CA 92697-4025, USA.
Thomas F MartinezDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Irvine, CA 92697-4025, USA; Department of Pharmaceutical Sciences, Chao Family Comprehensive Cancer Center, University of California Irvine School of Pharmacy and Pharmaceutical Sciences, Irvine, CA 92697-4025, USA. Electronic address: t.martinez@uci.edu.
Gina LeeDepartment of Microbiology and Molecular Genetics, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Irvine, CA 92697-4025, USA. Electronic address: ginalee85@gmail.com.
Cholsoon JangDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Irvine, CA 92697-4025, USA. Electronic address: choljang@uci.edu.

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Joel E Milam · 1994 to 2026
$57.9M
Identifying novel microproteins and protein translation mechanisms involved in the development of atherosclerosisF31HL182220 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Miranda Emiko Kelly · 2025 to 2026
$87k
NCI NIH HHS P30 CA062203NHLBI NIH HHS F31 HL182220
6 · The paper itself

Abstract

While kidneys are essential for maintaining systemic metabolic homeostasis and exhibit sexual dimorphism, the effects of sex and environmental factors, such as diet, on renal metabolism remain unclear. Using kidney-specific arteriovenous (AV) metabolomics, in vivo isotope tracing, and transcriptomics, we discover profound sex differences in kidney metabolic reprogramming under ketogenic diet (KD) in C57BL/6J mice. Tissue metabolomics shows the accumulation of aldosterone and acylcarnitines exclusively in female kidneys under a normal chow (NC) diet, suggesting basal sex differences in sodium and fatty acid metabolism. Under KD, AV metabolomics reveals that only female kidneys activate ketogenesis and gluconeogenesis, supported by transcriptional sex differences in related rate-limiting enzymes and transporters. Given the widespread public and clinical interest in KD for treating epilepsy, metabolic disorders, and cancers, our findings underscore the importance of considering sex differences in kidney metabolism as a fundamental variable when interpreting KD's diverse effects on pathophysiology and therapeutics.

Indexed as

aldosteronearteriovenousCP: metabolismgluconeogenesisketogenesisketogenic dietketone bodykidneymetabolic fluxmetabolomicssex difference

Identifiers

PMID41904948
PMCPMC13197013

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.