Evidence map›Paper›PMID 41904943›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

SAA/FPR2 Signaling Between Pericentral Hepatocytes and Macrophages Exacerbates Zonated Liver Transplant Injury.

Feng Zhang, Rong Li, Tingting Wang, Jianhao Zhang, Zhengqi Wu, Qiang You, Xuying Liu, Cuicui Xiao, Jiebin Zhang, Haitian Chen and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Feng ZhangDepartment of Hepatic Surgery and Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Rong LiGuangdong Provincial Key Laboratory of Liver Disease Research, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Tingting WangDepartment of Hepatic Surgery and Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Jianhao ZhangDepartment of Hepatic Surgery and Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Zhengqi WuDepartment of Hepatic Surgery and Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Qiang YouDepartment of Hepatic Surgery and Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Xuying LiuDepartment of Hepatic Surgery and Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Cuicui XiaoDepartment of Anesthesiology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Jiebin ZhangDepartment of Hepatic Surgery and Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Haitian ChenDepartment of Hepatic Surgery and Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Jiaqi XiaoDepartment of Hepatic Surgery and Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Jia YaoDepartment of Hepatic Surgery and Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Jun ZhengDepartment of Hepatic Surgery and Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Yingcai ZhangDepartment of Hepatic Surgery and Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Hua LiDepartment of Hepatic Surgery and Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Shuhong YiDepartment of Hepatic Surgery and Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Yang YangDepartment of Hepatic Surgery and Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Qi ZhangCell-gene Therapy Translational Medicine Research Center, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Xiaofeng YuanDepartment of General Intensive Care Unit, Lingnan Hospital, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Yasong LiuDepartment of Hepatic Surgery and Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.ORCID https://orcid.org/0000-0002-9919-2051

Funding

China Postdoctoral Science Foundation 2024M753770Guangzhou Basic and Applied Basic Research Key Foundation 2024B03J1382Guangzhou Basic and Applied Basic Research Project Co-funded by Municipal Schools (institutes) 2023A03J0727Guangzhou Basic and Applied Basic Research Project Co-funded by Municipal Schools (institutes) 2024A03J0273Guangzhou Basic and Applied Basic Research Project Co-funded by Municipal Schools (institutes) 2025A03J3196Liver Transplantation Program of People's Hospital of Xinjiang Uyghur Autonomous Region 20240101National Key Research and Development Program of China 2022YFA1104903National Key Research and Development Program of China 2024YFA1107200National Natural Science Foundation of China 82170674National Natural Science Foundation of China 82300747National Natural Science Foundation of China 82400770National Natural Science Foundation of China 82400771National Natural Science Foundation of China 82425010National Natural Science Foundation of China 82470666National Natural Science Foundation of China 82500761National Natural Science Foundation of China U24A20655Natural Science Foundation of Guangdong Province 2024A1515011662Natural Science Foundation of Guangdong Province 2025A1515010384Natural Science Foundation of Guangdong Province 2025A1515012524Youth Talent Cultivation Program of third Affiliated Hospital of SYSU 2024GZRPYMS07
6 · The paper itself

Abstract

Liver transplantation (LT) grafts exhibit selective pericentral hepatic ischemia-reperfusion injury (HIRI), but the zonal mechanism is unclear. To address this, we integrated single-cell and spatial transcriptomics with chromatin accessibility profiling, proteomics, and bulk RNA-seq, then validated key findings in clinical LT specimens, mouse HIRI models, and in vitro assays. Across datasets, HIRI disproportionately aggravated pericentral hepatocyte injury and markedly coincided with heightened macrophage crosstalk. Mechanistically, we identified FOXO1-dominated SAA secretion from pericentral hepatocytes that promotes FPR2

Indexed as

HepatocytesLiver TransplantationMacrophagesReceptors, Formyl PeptideReperfusion InjurySerum Amyloid A ProteinAnimalsForkhead Box Protein O1HumansLiverMaleMiceSignal TransductionForkhead Box Protein O1Receptors, Formyl PeptideSerum Amyloid A ProteinAmilo‐5MERhepatic ischemia‐reperfusion injuryliver transplantationliver zonationSAA/FPR2 signaling

Identifiers

PMID41904943
PMCPMC13285152

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.