ArticleInternational dental journal2026
Oral Microbiota and Cardiovascular Diseases: A Study Integrating Genome-Wide Association and 16S rRNA Sequence Analyses.
Article in International dental journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
INTRODUCTION AND
aimsEvidence suggests a relationship between oral microbiota and cardiovascular diseases (CVDs). However, the roles of specific microbiota in the pathogenesis of CVDs remain underexplored.
methodsTwo-sample mendelian randomization (MR) was applied to investigate the association between oral microbiota and six types of CVDs. Oral microbiota and CVDs were identified using large-scale genome-wide association study (GWAS) data from East Asian populations. Sequencing results from a clinical cohort were used to examine the directional consistency of the MR findings.
resultsThe MR analysis identified suggestive associations between specific oral bacteria and cardiovascular diseases, including 10 positive (risk factors) and 7 negative (protective factors) causative directions. Sensitivity analyses supported the robustness of these associations. Clinical observational analysis showed that seven risk-associated and 2 protective bacteria were significantly correlated with CVDs, demonstrating directional consistency with the MR findings.
conclusionUsing GWAS datasets and MR analysis, this study systematically investigated the relationships between oral microbiota and six distinct subtypes of CVDs and identified specific oral bacteria as potential targets for further investigation into CVDs prevention.
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