Evidence map›Paper›PMID 41904793›Full record

ArticleCirculation. Cardiovascular interventions2026

Diagnostic Yield and Safety of Invasive Coronary Function Testing After Radial Versus Femoral Access.

Fleur W Adriaansen, Caïa Crooijmans, Tijn P J Jansen, Behruz Yosofi, Joan G Meeder, Yolande Appelman, Marcel A M Beijk, Tim P van de Hoef, Timo Nijkamp, Hester M den Ruijter and 21 more

Abstract readComparative StudyMulticenter Study
In one paragraph

Article in Circulation. Cardiovascular interventions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Radial Access Strategies: Focus on Coronary Function Testing for Angina With Nonobstructive Coronary Arteries.Journal of the Society for Cardiovascular Angiography & Interventions · 2026
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

31 authors.

Fleur W AdriaansenDepartment of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands (F.W.A., C.C., T.P.J.J., B.Y., J.H.C., N.v.R., S.E.E.-S., A.C.D.-L., P.D.).ORCID 0009-0005-6130-8353
Caïa CrooijmansDepartment of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands (F.W.A., C.C., T.P.J.J., B.Y., J.H.C., N.v.R., S.E.E.-S., A.C.D.-L., P.D.).ORCID 0000-0002-9253-5154
Tijn P J JansenDepartment of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands (F.W.A., C.C., T.P.J.J., B.Y., J.H.C., N.v.R., S.E.E.-S., A.C.D.-L., P.D.).ORCID 0000-0002-9615-9491
Behruz YosofiDepartment of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands (F.W.A., C.C., T.P.J.J., B.Y., J.H.C., N.v.R., S.E.E.-S., A.C.D.-L., P.D.).ORCID 0000-0001-6785-3348
Joan G MeederDepartment of Cardiology, VieCuri Medical Center, Venlo, The Netherlands (J.G.M.).ORCID 0000-0003-3261-9361
Yolande AppelmanDepartment of Cardiology, Amsterdam University Medical Center, The Netherlands (Y.A., M.A.M.B.).ORCID 0000-0001-5241-7105
Marcel A M BeijkDepartment of Cardiology, Amsterdam University Medical Center, The Netherlands (Y.A., M.A.M.B.).ORCID 0000-0002-7984-3021
Tim P van de HoefDepartment of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands (T.P.v.d.H., T.N.).ORCID 0000-0003-0682-0619
Timo NijkampDepartment of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands (T.P.v.d.H., T.N.).ORCID 0009-0005-2952-4849
Hester M den RuijterLaboratory of Experimental Cardiology, University Medical Center Utrecht, The Netherlands (H.M.d.R.).ORCID 0000-0001-9762-014X
Annemiek M J de VosDepartment of Cardiology, Catharina Hospital, Eindhoven, The Netherlands (A.M.J.d.V.).ORCID 0000-0003-4613-6774
Valeria ParadiesDepartment of Cardiology, Maasstad Hospital, Rotterdam, The Netherlands (V.P.).ORCID 0000-0003-3513-7819
Martijn MeuwissenDepartment of Cardiology, Amphia Hospital, Breda, The Netherlands (M.M.).ORCID 0000-0002-5421-5205
Nicola S VosDepartment of Cardiology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands (N.S.V.).
Els G M Olde BijvankDepartment of Cardiology, Haaglanden Medical Center, Den Haag, The Netherlands (E.G.M.O.B.).
Ibtihal Al AmriDepartment of Cardiology, Leiden University Medical Center, The Netherlands (I.A.A., M.C.d.H.).
Melina C den HaanDepartment of Cardiology, Leiden University Medical Center, The Netherlands (I.A.A., M.C.d.H.).ORCID 0000-0003-4835-5268
Jonathan HalimDepartment of Cardiology, Elisabeth-Tweesteden Hospital, Tilburg, The Netherlands (J.H.).
Stijn C H van den OordDepartment of Cardiology, Rijnstate Hospital, Arnhem, The Netherlands (S.C.H.v.d.O.).
Karin ArkenboutDepartment of Cardiology, Tergooi Medical Center, Hilversum, The Netherlands (K.A.).
Marlies M KokDepartment of Cardiology, Medical Spectrum Twente, Enschede, The Netherlands (M.M.K.).ORCID 0000-0003-0101-2217
Pier WoudstraDepartment of Cardiology, Frisius Medical Center, Leeuwarden, The Netherlands (P.W., T.N.E.V.).ORCID 0000-0002-5870-9923
Tessel N E VossenbergDepartment of Cardiology, Frisius Medical Center, Leeuwarden, The Netherlands (P.W., T.N.E.V.).ORCID 0000-0003-1122-2429
Nick D FagelDepartment of Cardiology, Noordwest Hospital Group, Alkmaar, The Netherlands (N.D.F., T.A.C.M.H., J.H.C.).ORCID 0009-0008-1005-7293
Ton A C M HeestermansDepartment of Cardiology, Noordwest Hospital Group, Alkmaar, The Netherlands (N.D.F., T.A.C.M.H., J.H.C.).
Jan H CornelDepartment of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands (F.W.A., C.C., T.P.J.J., B.Y., J.H.C., N.v.R., S.E.E.-S., A.C.D.-L., P.D.).ORCID 0000-0002-1006-2112
Niels van RoyenDepartment of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands (F.W.A., C.C., T.P.J.J., B.Y., J.H.C., N.v.R., S.E.E.-S., A.C.D.-L., P.D.).ORCID 0000-0001-6136-8640
Suzette E Elias-SmaleDepartment of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands (F.W.A., C.C., T.P.J.J., B.Y., J.H.C., N.v.R., S.E.E.-S., A.C.D.-L., P.D.).ORCID 0000-0003-1351-1582
Aukelien C Dimitriu-LeenDepartment of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands (F.W.A., C.C., T.P.J.J., B.Y., J.H.C., N.v.R., S.E.E.-S., A.C.D.-L., P.D.).
Peter DammanDepartment of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands (F.W.A., C.C., T.P.J.J., B.Y., J.H.C., N.v.R., S.E.E.-S., A.C.D.-L., P.D.).ORCID 0000-0002-9284-7967
for NL-CFT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCoronary vasomotor dysfunction is diagnosed by a coronary function testing (CFT). However, protocols vary, and the influence of access site and concomitant vasodilator medication on the diagnostic yield and safety of CFT is unclear. This study assessed the diagnostic yield and safety of CFT by radial access with intraarterial calcium channel blockers compared with CFT by femoral access.

methodsData were obtained from the Netherlands Registry of Invasive Coronary Vasomotor Function Testing, a Dutch multicenter collaboration on CFT. Patients who underwent CFT between December 2020 and July 2025 were included.

resultsA total of 1885 patients were included, 1436 (76.2%) with primary radial access and 380 (20.2%) with primary femoral access. In 69 (3.7%) patients conversion from radial to femoral access was necessary. The conversion group was analyzed separately. The total diagnostic yield of coronary vasomotor dysfunction was 78.5%. There was no significant difference in the prevalence of coronary vasomotor dysfunction between patients with primary radial versus femoral access (79.2% versus 75.3%;

conclusionsPrimary radial access with routine administration of calcium channel blockers was not associated with a lower diagnostic yield in CFT than primary femoral access. Procedural safety was comparable.

Indexed as

Cardiac CatheterizationCatheterization, PeripheralCoronary Artery DiseaseFemoral ArteryRadial ArteryAgedCalcium Channel BlockersFemaleHumansMaleMiddle AgedNetherlandsPredictive Value of TestsRegistriesRisk AssessmentRisk FactorsCalcium Channel BlockersVasodilator Agentscoronary vasospasmhumansmicrovascular anginaprevalenceregistriesvasodilator agents

Identifiers

PMID41904793
PMCPMC13281970

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.