Pushing the limits of spatial resolution in clinical PCD-CT using a dedicated high-resolution convolutional neural network (HR-CNN).

backgroundPhoton-counting-detector (PCD) CT systems offer ultra-high spatial resolution, yet the visual spatial resolution on clinical images often constrained by large pixel size, yielding resolutions below system capabilities. While reducing pixel size and using sharp kernels enhance visual spatial resolution, it increases noise, compromising image quality. PURPOSE: To investigate the combined effects of pixel size and reconstruction kernels on visual spatial resolution using phantom and clinical images and to develop a dedicated high-resolution deep convolutional neural network (HR-CNN) to better utilize the intrinsic high spatial resolution of PCD-CT in clinical imaging.

methodsThe relationship between spatial resolution, reconstruction kernel, and pixel size was investigated to identify strategies for utilizing the full spatial resolution potential of PCD-CT. To overcome the increased noise associated with high-resolution settings, a dedicated HR-CNN was developed to push the limit of spatial resolution in routine PCD-CT exams. The HR-CNN was trained using patient exams acquired with ultra-high-resolution (UHR) mode and reconstructed with a 150-mm field of view (FOV), matrix size of 1024×1024 (0.15-mm pixel size) and sharpest quantitative kernel (Qr89). The impact of FOV, kernel, and denoising on spatial resolution was studied using bar-pattern phantoms and a pilot clinical evaluation including 5 patients with interstitial lung diseases. Two thoracic radiologists evaluated 4 different FOV/reconstruction conditions: (1) FOV-410/Qr56-Iterative reconstruction (IR), (2) FOV-410/Qr89-IR, (3) FOV-150/Qr89-IR, and (4) FOV-150/Qr89-HR-CNN in terms of overall image quality, noise, visual spatial resolution, and overall preference.

resultsWith a FOV of 410 mm, the Qr89 sharp kernel displayed bar-patterns up to 14 lp/cm, not much higher than the routine lung kernel Qr56. When the FOV was reduced to 150 mm, Qr89-IR allowed for the visualization of line pair patterns ranging from 18 to 20 lp/cm, with 20 lp/cm being moderately discernible. The application of Qr89-HR-CNN yielded further improvement, enabling the display of line pair patterns as high as 20-22 lp/cm. In patient cases, both radiologists consistently ranked the FOV-150 images processed with HR-CNN as superior across metrics including overall image quality, noise reduction, visual spatial resolution, and overall preference. The HR-CNN reduced the noise in patients' images by 93.0 ± 0.6% and 44.9 ± 5.3% in comparison with the original FBP and IR images, respectively.

conclusionsThe spatial resolution of PCD-CT is not maximized in routine practice due to the large FOV and high noise levels at sharp kernels. The proposed HR-CNN denoising method, along with small pixel size, may allow the high spatial resolution toward the system limit to be implemented in practice, which is beneficial in the diagnosis of many diseases, including interstitial lung disease.