ArticleBMC research notes2026
The changes of inflammatory biomarkers after a 12-week home-based aerobic and resistance exercise intervention in breast cancer survivors.
Article in BMC research notes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07338903 (Move to Improve), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Move to Improve: Investigating the Feasibility of Embedding Physical Activity Into Routine Breast Cancer Care in Indonesia
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11 authors.
Funding
Abstract
objectiveOur earlier work reported the benefits of implementing a 12-week home-based aerobic and resistance exercise in breast cancer patients. Other studies showed a correlation between increased physical function from exercise with the reduction of inflammatory biomarkers. This study aimed to analyse the changes of exercise-induced inflammatory biomarkers and its association with health-related outcomes.
resultsA 12-week home-based exercise intervention was assigned to 32 breast cancer patients, consisting of pedometer-driven walking (aerobic) and resistance exercise using therapeutic bands. C-reactive protein (CRP), interleukin-6 (IL-6), and interleukin-10 (IL-10) levels, and other health-related outcomes including physical function, resting heart rate (RHR), physical activity levels, and fatigue, were assessed before and after intervention. Wilcoxon signed rank test revealed significant changes in CRP levels post-intervention (P = 0.043). The IL-6 and IL-10 levels were increased post-intervention but the majority of IL-6 and IL-10 levels were below lower level of quantification (LLOQ). The median changes from pre- to post-intervention were 0.2 mg/dL for CRP, 0 pg/mL for IL-6, and 0.62 pg/mL for IL-10. CRP changes ≤ 0.2 mg/dL were associated with improved fatigue (P = 0.003), IL-6 changes > 0 pg/mL might be associated with increased moderate-intensity physical activity levels (P = 0.009), and IL-10 changes > 0.62 pg/mL might be associated with increased moderate-intensity physical activity levels (P = 0.008) and RHR reduction (P = 0.026). These findings suggested that inflammatory biomarker changes were related to exercise-induced benefits. Trial registration This study was registered in the ClinicalTrials.gov Database (ID NCT07338903), with retrospective registration completed on 4 January 2026.
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