Evidence map›Paper›PMID 41904483›Full record

ArticleTrials2026

Personalized hemodynamic management targeting preoperative baseline cardiac index in high-risk patients having major abdominal surgery: rationale and design of the international multicenter randomized PELICAN trial.

Moritz Flick, Eske Kvanner Aasvang, Michael Eichlseder, Adam Klimovic, Agnes S Meidert, Christian Sylvest Meyhoff, Sebastian Roth, Moritz Steinhaus, Rune Sort, Marc Vives and 7 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05648279 (Personalized Hemodynamic Management Targeting Preoperative Baseline Cardiac Index in High-risk Patients Having Major Abdominal Surgery), which is not on this map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05648279 nacompletednot on this map

Personalized Hemodynamic Management Targeting Preoperative Baseline Cardiac Index in High-risk Patients Having Major Abdominal Surgery: the International Multicenter Randomized PELICAN Trial

TypeinterventionalSponsorUniversitätsklinikum Hamburg-EppendorfRan2023 to 2026Enrolled1,128ConditionsCardiac Output, Surgery, Postoperative Complications, AnesthesiaArmsPersonalized hemodynamic management
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

17 authors.

Moritz FlickDepartment of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Eske Kvanner AasvangDepartment of Anaesthesiology, Centre for Cancer and Organ Diseases, Rigshospitalet, Copenhagen University Hospital, Copenhagen University, Copenhagen, Denmark.
Michael EichlsederDivision of Anaesthesiology and Intensive Care 1, Department of Anaesthesiology and Intensive Care, Medical University of Graz, Graz, Austria.
Adam KlimovicDepartment of Anesthesiology, Resuscitation and Intensive Care, Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic.
Agnes S MeidertDepartment of Anaesthesiology, LMU University Hospital, LMU Munich, Munich, Germany.
Christian Sylvest MeyhoffDepartment of Anaesthesia and Intensive Care, Copenhagen University Hospital-Bispebjerg and Frederiksberg, Copenhagen, Denmark.
Sebastian RothDepartment of Anesthesiology, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Moritz SteinhausDepartment of Anesthesiology and Intensive Care, University of Lübeck and University Medical Center Schleswig-Holstein, Lübeck, Germany.
Rune SortDepartment of Anaesthesiology, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.
Marc VivesDepartment of Anesthesia & Critical Care, Clínica Universidad de Navarra, Pamplona, Spain.
Benjamin VojnarDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Giessen and Marburg, Campus Marburg and Philipps-University of Marburg, Marburg, Germany.
Sebastian ZiemannDepartment of Anaesthesiology, Medical Faculty, RWTH Aachen University Hospital, Aachen, Germany.
Linda KrauseInstitute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Eik VettorazziInstitute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Antonia ZapfInstitute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Karim KouzDepartment of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Bernd SaugelDepartment of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. bcs.muc@gmx.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntraoperative hemodynamic management is intended to ensure adequate tissue perfusion and oxygen delivery and eventually help avoid organ injury. However, the optimal strategy for intraoperative hemodynamic management in patients having non-cardiac surgery remains unclear. We here report the protocol of a trial designed to test the hypothesis that personalized intraoperative hemodynamic management targeting preoperative baseline cardiac index reduces the incidence of a composite outcome of major postoperative complications and death within 7 days after surgery compared to routine hemodynamic management in high-risk patients having elective major abdominal surgery.

methodsThe PELICAN trial is an international multicenter randomized trial in 1,128 high-risk patients having elective major abdominal surgery. The individual preoperative baseline cardiac index is determined with the patient being awake and resting in the supine position using noninvasive bioreactance. Patients are randomized to personalized hemodynamic management (intervention) or to routine hemodynamic management (control) during surgery. In patients assigned to personalized hemodynamic management, intraoperative cardiac index is maintained at least at the preoperative baseline cardiac index. In patients assigned to routine hemodynamic management, it is performed as per anesthesiologist preference (with blinded cardiac index monitoring). The primary outcome is the incidence of a composite outcome ("any event versus none") of acute kidney injury, acute myocardial injury (including myocardial infarction), non-fatal cardiac arrest, severe infectious complications, and death within 7 days after surgery. DISCUSSION: Our trial will determine whether personalized intraoperative hemodynamic management targeting preoperative baseline cardiac index reduces the incidence of major postoperative complications and death within 7 days in high-risk patients having elective major abdominal surgery compared to routine hemodynamic management.

trial registrationClinicalTrials.gov Identifier NCT05648279. Registered on 5 December 2022.

Indexed as

AbdomenHemodynamicsPostoperative ComplicationsPrecision MedicinePreoperative CareElective Surgical ProceduresHumansMulticenter Studies as TopicRandomized Controlled Trials as TopicRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeAcute kidney injuryAcute myocardial injuryAnesthesiaBioreactanceCardiac outputGoal-directed therapyHemodynamic monitoringOutcomePerioperative medicine

Identifiers

PMID41904483
PMCPMC13064272

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.