ArticleTechniques in coloproctology2026
Mortality trends from colorectal pathologies in the United States (1999-2020): a retrospective cohort study using CDC WONDER.
Article in Techniques in coloproctology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundColorectal diseases encompass both malignant and benign conditions with significant public health implications. While colorectal cancer (CRC) mortality has been well characterized, population-level mortality trends for benign colorectal conditions remain poorly defined.
methodsThis retrospective cohort study analyzed mortality data for U.S. decedents aged ≥15 years from 1999-2020 using the CDC WONDER database. Underlying causes of death were categorized as CRC, inflammatory bowel disease (IBD), or benign colorectal conditions. Crude death rates (CDRs) per million were calculated, and temporal trends were evaluated using Joinpoint regression to estimate annual percent change (APC).
resultsOf 56,014,102 total deaths, 1,560,448 (2.7%) were due to colorectal pathologies. CRC accounted for most deaths (CDR 216.2), followed by benign colorectal conditions (68.5) and IBD (3.8) (p0.001). Among benign causes, Clostridioides difficile enterocolitis (CDR 21.6) was the leading contributor, followed by diverticular disease (12.4) and acute vascular intestinal disorders (9.0). CRC mortality declined significantly (AAPC -1.44%, p0.05), whereas benign colorectal and IBD mortality remained stable.
conclusionsMortality from benign colorectal conditions has persisted over two decades despite major declines in CRC mortality, highlighting unmet needs in research and prevention. Future public health efforts should extend beyond malignancy to address preventable deaths from benign colorectal disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.