Evidence map›Paper›PMID 41904323›Full record

ArticleThe EMBO journal2026

CDKAL1 dysfunction impairs lysine codon translation in podocytes and accelerates chronic kidney disease.

Hiroko Nagata, Yu Nagayoshi, Takeshi Chujo, Hitomi Kaneko, Kayo Nishiguchi, Yutaka Kakizoe, Hiroko Ijima, Korin Sakakida, Takeshi Masuda, Sumio Ohtsuki and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Hiroko NagataDepartment of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.ORCID http://orcid.org/0000-0002-0958-8504
Yu NagayoshiDepartment of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Takeshi ChujoDepartment of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.ORCID http://orcid.org/0000-0003-2393-5776
Hitomi KanekoDepartment of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.ORCID http://orcid.org/0009-0003-1801-9674
Kayo NishiguchiDepartment of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Yutaka KakizoeDepartment of Nephrology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Hiroko IjimaDepartment of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Korin SakakidaDepartment of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Takeshi MasudaInstitute for Advanced Biosciences, Keio University, Tsuruoka, Japan.
Sumio OhtsukiDepartment of Pharmaceutical Microbiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Fan-Yan WeiDepartment of Modomics Biology and Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Yukie TakahashiDepartment of Anatomy and Neurobiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Takaichi FukudaDepartment of Anatomy and Neurobiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Hideaki JinnouchiJinnouchi Hospital, Kumamoto, Japan.
Yuki AdachiDepartment of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Ryosuke YamamuraDepartment of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Koki MatsushitaDepartment of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Masataka AdachiDepartment of Nephrology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Hideki YokoiDepartment of Nephrology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Kimitoshi NakamuraDepartment of Pediatrics, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Hitoshi NakazatoDepartment of Pediatrics, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Kazuhito TomizawaDepartment of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan. tomikt@kumamoto-u.ac.jp.ORCID http://orcid.org/0000-0002-5663-2627

Funding

Japan Agency for Medical Research and Development (AMED) JP23ama121018MEXT | Japan Society for the Promotion of Science (JSPS) 21K20925MEXT | Japan Society for the Promotion of Science (JSPS) 22K16224MEXT | Japan Society for the Promotion of Science (JSPS) 25K02702
6 · The paper itself

Abstract

Cdk5 regulatory subunit-associated protein 1-like 1 (Cdkal1) encodes a tRNA-modifying enzyme responsible for thiomethylation generating 2-methylthio-N

Indexed as

CodonLysinePodocytesProtein BiosynthesisRenal Insufficiency, ChronictRNA MethyltransferasesAnimalsMiceMice, KnockoutCDKAL1 protein, mouseCodonLysinetRNA MethyltransferasesCDKAL1Chronic Kidney Disease (CKD)Lysine Codon TranslationPodocyte DysfunctiontRNA Modification Enzyme

Identifiers

PMID41904323
PMCPMC13144697

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.