Evidence map›Paper›PMID 41904270›Full record

ArticleMolecular psychiatry2026

Pallidal and subthalamic stimulations modulate inter-hemispheric interaction and asymmetry in Parkinson's disease.

Siyuan Mei, Naying He, Weibin He, Junyi Yan, Chunguang Chu, Zhitong Zeng, Fuhua Yan, Dianyou Li, Yi Pu, Chencheng Zhang and 1 more

Abstract read
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In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Siyuan Mei *Department of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou, China.
Naying He *Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Weibin HeClinical Neuroscience Center, RuiJin-Mihoyo Laboratory, RuiJin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Junyi YanClinical Neuroscience Center, RuiJin-Mihoyo Laboratory, RuiJin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chunguang ChuSchool of Electrical and Information Engineering, Tianjin University, Tianjin, China.
Zhitong ZengDepartment of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Fuhua YanDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Dianyou LiDepartment of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0003-4212-4231
Yi PuShanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), School of Psychology and Cognitive Science, East China Normal University, Shanghai, China. ypu@psy.ecnu.edu.cn.
Chencheng ZhangClinical Neuroscience Center, RuiJin-Mihoyo Laboratory, RuiJin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. i@cczhang.org.ORCID http://orcid.org/0000-0003-4472-4134
Xiang-Zhen KongDepartment of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou, China. xiangzhen.kong@zju.edu.cn.ORCID http://orcid.org/0000-0002-0805-1350

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32400882
6 · The paper itself

Abstract

Substantial asymmetries of motor dysfunction are evident in patients with Parkinson's disease (PD), the mechanisms of which remain largely unexplored. This study investigated how deep brain stimulation (DBS) targeting the globus pallidus interna (GPi) and subthalamic nucleus (STN) modulates characteristics of hemispheric lateralization in PD patients, with particular emphasis on motor asymmetries and hemispheric integration (via homotopic functional connectivity) and segregation (via hemispheric asymmetry in connectivity). Resting-state functional magnetic resonance imaging (fMRI) and Unified Parkinson's Disease Rating Scale (UPDRS) III scores were analyzed from 55 PD patients who underwent either bilateral GPi- or STN-DBS. Both targets produced significant improvements in motor function. Notably, stimulation effects on motor asymmetry depend on patients' baseline asymmetry direction (DBS OFF): STN-DBS consistently reduced asymmetry in the leftward-asymmetry patients, whereas GPi-DBS has stronger effects in rightward patients. In both cases, stimulation led to a more symmetric pattern. Beyond motor outcomes, motor gains were associated with changes in homotopic connectivity in the lateral occipital region, overlapping the extrastriate body area, suggesting a compensatory role of visual networks. These findings highlight the contribution of the visual networks to motor improvement and reveal target-dependent effects of DBS on both motor asymmetry and non-motor cognitive domains.

Indexed as

Deep Brain StimulationFunctional LateralityGlobus PallidusParkinson DiseaseSubthalamic NucleusAgedBrain MappingFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeural Pathways

Identifiers

PMID41904270

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.