SynthesisScientific reports2026
Efficacy of focused ultrasound for HPV clearance and cervical LSIL treatment: a meta-analysis.
Synthesis in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Persistent high-risk human papillomavirus (hrHPV) infection is a major risk factor for high-grade squamous intraepithelial lesions (HSIL) and cervical cancer. Although HPV vaccines effectively prevent infections with vaccine-covered HPV types, they do not eliminate established infections. Additionally, not all HPV types associated with cervical cancer are covered by the vaccine. Therefore, treatment strategies for HPV-related cervical lesions remain an important clinical challenge. A systematic search was conducted in PubMed, EMBASE, Web of Science, and the Cochrane Library to identify studies evaluating the efficacy of focused ultrasound in treating HPV and cervical low-grade squamous intraepithelial lesions (LSIL). Ten eligible observational studies were included. Study quality was assessed using the MINORS criteria, and evidence quality was evaluated based on GRADE guidelines. A meta-analysis was performed using Stata 12.0 software. Focused ultrasound treatment led to HPV clearance in 74% of cases (ES = 0.74, 95% CI: 0.64-0.85, P < 0.001). Additionally, 94% of women with LSIL histology before treatment had a normal cervical biopsy at follow-up (ES = 0.94, 95% CI: 0.92-0.97, P < 0.001), and 87% of women with abnormal ThinPrep cytology (TCT) results had normal cytology at follow-up (ES = 0.87, 95% CI: 0.78-0.96, P < 0.001). Compared to the observation group, focused ultrasound treatment was significantly more effective in clearing HPV (OR = 3.58, 95% CI: 2.21-5.81, P < 0.001). Similarly, focused ultrasound was superior to interferon treatment for HPV clearance (OR = 4.22, 95% CI: 1.12-15.96, P = 0.034). The quality of evidence across studies was rated as low to moderate. This meta-analysis demonstrates that focused ultrasound achieves a 74% HPV clearance rate and 94% LSIL resolution in women with cervical LSIL and concurrent hrHPV infection. While superior to observation and interferon, the evidence remains low-to-moderate due to the observational nature and geographic concentration of included studies. Future multicenter RCTs are essential to validate these results and assess long-term outcomes, including recurrence and obstetric safety.
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