Multi-parametric interferometric reflectance imaging sensor.

Mete Aslan, Stephen Snekvik, Elif Seymour, Sinem Diken Gür, Eren Ergene, Nese Lortlar Ünlü, M Selim Ünlü

Abstract read

In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mete Aslan *Department of Electrical and Computer Engineering, Boston University, 8 St. Mary's St., Boston, MA, 02125, USA.

Stephen Snekvik *Department of Electrical and Computer Engineering, Boston University, 8 St. Mary's St., Boston, MA, 02125, USA.

Elif SeymourIRIS Kinetics, 650 Albany St., Boston, MA, 02118, USA.

Sinem Diken GürDepartment of Electrical and Computer Engineering, Boston University, 8 St. Mary's St., Boston, MA, 02125, USA.

Eren ErgeneDepartment of Biomedical Engineering, Boston University, 8 St. Mary's St., Boston, MA, 02125, USA.

Nese Lortlar ÜnlüDepartment of Medicine, Atlas University, 34580, Istanbul, Turkey.

M Selim ÜnlüDepartment of Electrical and Computer Engineering, Boston University, 8 St. Mary's St., Boston, MA, 02125, USA. selim@bu.edu.

Funding

National Science Foundation 2329817

6 · The paper itself

Abstract

We present a dual-wavelength, multi-parametric Interferometric Reflectance Imaging Sensor (MP-IRIS) for real-time, label free, multiplexed binding kinetic measurements without the "bulk-effect". Our platform dynamically tracks the conditions of the solution and corrects in real time, demonstrating a reduction in bulk effect to 3 pg/mm[Formula: see text] with bulk refractive index change of [Formula: see text] RIU. By incorporating multi-wavelength data acquisition, we improve the repeatability and reduce quantification error due to variation in chip manufacturing and surface treatment. Proof-of-concept DNA hybridization assays validate accurate, multiplexed binding measurements under diverse chip conditions. MP-IRIS retains the high sensitivity of prior IRIS designs, lowering the overall complexity of the system and offering potential applications in small-molecule analysis.

Identifiers

PMID41904214

DOI10.1038/s41598-026-45282-x

PMCPMC13039672

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Textmetadata

LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.