Evidence map›Paper›PMID 41904158›Full record

ArticleNature communications2026

Unlocking the reactivity of difluoroketene and its synthetic applications.

Sheng Xi, Chi Zhang, Liying Fu, Hai-Xiang Gao, Wenjing Jia, Hongrui Zhang, Yuting Liu, Xue-Qiang Chu, Yu Zhang, Kai Guo and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sheng Xi *Technical Institute of Fluorochemistry (TIF), Institute of Advanced Synthesis (IAS), School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing, China.
Chi Zhang *Technical Institute of Fluorochemistry (TIF), Institute of Advanced Synthesis (IAS), School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing, China.
Liying Fu *Technical Institute of Fluorochemistry (TIF), Institute of Advanced Synthesis (IAS), School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing, China.
Hai-Xiang GaoTechnical Institute of Fluorochemistry (TIF), Institute of Advanced Synthesis (IAS), School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing, China.
Wenjing JiaTechnical Institute of Fluorochemistry (TIF), Institute of Advanced Synthesis (IAS), School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing, China.
Hongrui ZhangTechnical Institute of Fluorochemistry (TIF), Institute of Advanced Synthesis (IAS), School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing, China.
Yuting LiuTechnical Institute of Fluorochemistry (TIF), Institute of Advanced Synthesis (IAS), School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing, China.
Xue-Qiang ChuTechnical Institute of Fluorochemistry (TIF), Institute of Advanced Synthesis (IAS), School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing, China.
Yu ZhangCollege of Chemical Engineering, Nanjing Forestry University, Nanjing, China.
Kai GuoCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China. guok@njtech.edu.cn.ORCID http://orcid.org/0000-0002-0013-3263
Chao FengTechnical Institute of Fluorochemistry (TIF), Institute of Advanced Synthesis (IAS), School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing, China. iamcfeng@njtech.edu.cn.ORCID http://orcid.org/0000-0003-4494-6845

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22271151National Natural Science Foundation of China (National Science Foundation of China) 22301133National Natural Science Foundation of China (National Science Foundation of China) 22571158
6 · The paper itself

Abstract

Discovery and application of reactive intermediates has prominently expedited the development of organic chemistry. In this respect, while ketene has been well recognized as a versatile intermediate for a wide range of transformations, practical application of difluoroketene remained virtually unrealized because of its highly reactive nature. Herein, we present a transition-metal-free approach for in situ generation of difluoroketene using difluorobromoacetylsilane as a precursor. The controlled release of chemically labile difluoroketene under mild conditions, achieved through desilylative β-elimination, establishes a foundation for successful development of its Belluš-Claisen rearrangement with allylic amines, Staudinger [2 + 2] cycloaddition with imines, [4 + 2] cycloaddition, as well as insertion into alcohols, amines, and thiols for their difluoroacetylation. A series of mechanistic experiments provide concrete support for the involvement of difluoroketene in these transformations.

Identifiers

PMID41904158
PMCPMC13194789

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.