Evidence map›Paper›PMID 41904156›Full record

ArticleCell death & disease2026

Deltex E3 ubiquitin ligase 2 potentiates STING-mediated type I interferon response by K63-linked ubiquitination.

Zhuang Liu, Runze Li, Caihong Fan, Yuheng Liu, Jia Liu, Mingchen Yin, Ni Shang, Xudong Wang, Zhi Qi, Yanna Shen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhuang Liu *Department of Head and Neck Oncology, Tianjin Medical University Cancer Institute & Hospital, Key Laboratory of Basic and Translational Medicine on Head & Neck Cancer, Tianjin; National Clinical Research Center for Cancer; Tianjin's Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin Medical University, Tianjin, China.
Runze Li *Division of Medical Technology, Tianjin Medical University, Tianjin, China.
Caihong Fan *Division of Medical Technology, Tianjin Medical University, Tianjin, China.
Yuheng LiuDivision of Medical Technology, Tianjin Medical University, Tianjin, China.
Jia LiuDivision of Medical Technology, Tianjin Medical University, Tianjin, China.ORCID http://orcid.org/0009-0001-1034-3168
Mingchen YinDivision of Medical Technology, Tianjin Medical University, Tianjin, China.
Ni ShangDivision of Medical Technology, Tianjin Medical University, Tianjin, China.
Xudong WangDepartment of Head and Neck Oncology, Tianjin Medical University Cancer Institute & Hospital, Key Laboratory of Basic and Translational Medicine on Head & Neck Cancer, Tianjin; National Clinical Research Center for Cancer; Tianjin's Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin Medical University, Tianjin, China. wxd.1133@163.com.ORCID http://orcid.org/0000-0003-0437-3616
Zhi QiDepartment of Molecular Pharmacology, School of Medicine; Beichen Hospital, Nankai University, Tianjin, China. qizhi@nankai.edu.cn.
Yanna ShenDivision of Medical Technology, Tianjin Medical University, Tianjin, China. shenyanna@tmu.edu.cn.ORCID http://orcid.org/0000-0001-5643-1916
Chang LiuDivision of Medical Technology, Tianjin Medical University, Tianjin, China. liuchang419@tmu.edu.cn.ORCID http://orcid.org/0000-0002-9594-5810

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stimulator of interferon genes (STING) signaling, as a pivotal DNA-sensing mechanism, orchestrates antiviral and antitumor immunity through the induction of type I interferon response. Precise modulation of STING signaling is critical for maintaining immune homeostasis, yet its regulatory landscape has not been fully elucidated. Here, we identify the Deltex E3 ubiquitin ligase 2 (DTX2) as a positive regulator of STING-type I interferon response. Loss of Dtx2 in mouse macrophages and embryonic fibroblasts (MEFs) markedly impairs the type I interferon production upon double-stranded DNA (dsDNA) or cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) (cGAMP) stimulation. Correspondingly, Dtx2

Indexed as

Interferon Type IMembrane ProteinsUbiquitinationUbiquitin-Protein LigasesAnimalscGAS-STING Signaling PathwayCytokinesEndoplasmic ReticulumGolgi ApparatusHEK293 CellsHumansMacrophagesMiceMice, Inbred C57BLMice, KnockoutSignal TransductionCytokinesG1p2 protein, mouseInterferon Type IMembrane ProteinsSTING1 protein, humanSting1 protein, mouseSTING ProteinUbiquitin-Protein LigasesUbiquitins

Identifiers

PMID41904156
PMCPMC13150011

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.