Evidence map›Paper›PMID 41904139›Full record

ArticleNature communications2026

Metal-dependent and metal-free mechanisms of peptide condensate catalysts.

Tlalit Massarano, Yuqin Yang, Avigail Baruch Leshem, Ori Eran, Xiaoyu Wang, Hao Dong, Ayala Lampel

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tlalit Massarano *Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.ORCID http://orcid.org/0009-0004-7825-0242
Yuqin Yang *State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing, China.ORCID http://orcid.org/0000-0002-2751-5499
Avigail Baruch LeshemShmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
Ori EranShmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
Xiaoyu WangState Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing, China.
Hao DongState Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing, China. donghao@nju.edu.cn.ORCID http://orcid.org/0000-0001-7280-7506
Ayala LampelShmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel. ayalalampel@tauex.tau.ac.il.ORCID http://orcid.org/0000-0003-2733-9197

Funding

Israel Science Foundation (ISF) 3217/23
6 · The paper itself

Abstract

Condensates formed via liquid-liquid phase separation (LLPS) provide a chemically versatile environment for catalysis through dynamic molecular interactions. We present designed biomolecular condensates, formed by LLPS of minimalistic histidine-containing peptides, catalyzing ester hydrolysis with two distinct mechanisms. Zn

Indexed as

CatalysisHistidineWaterZincHydrogen BondingHydrolysisHistidineWaterZinc

Identifiers

PMID41904139
PMCPMC13194831

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.