ArticleNature communications2026
Determinants of chromosome-specific telomere lengths among 2573 All of Us participants.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- How telomere attrition protects against cancer.Nature reviews. Genetics · 2026Review
- Single-molecule variation in telomeric sequence and structure across humans.bioRxiv : the preprint server for biology · 2026Article
- Determinants of chromosome-specific telomere lengths among 2573 All of Us participants.Nature communications · 2026Article
Corrections and comments
- Update of
Authors and funding
8 authors.
Funding
Abstract
Telomere length is a biomarker of aging and disease risk. Most human studies have assessed average telomere length, limiting our understanding of variability across chromosome arms. Using long-read sequencing data from >2500 All of Us participants, we estimate chromosome-specific telomere lengths and characterize sources of biological and technical variation. Telomere length varies by chromosome arm, accounting for 9.1% of total variance. Substantial variance (8.9%) in chromosome-specific telomere lengths is attributable to individual, independent of age, suggesting that inter-individual differences in length are established at birth and maintained through life. Age is inversely associated with length for all arms, but longer arms show stronger association. We demonstrate that chromosome-specific telomere estimates enable analysis of disease associations for individual telomeres and for individuals' shortest telomere. Overall, this work highlights the utility of long-read sequencing for population-scale analysis of chromosome-specific telomere lengths and provides a framework to guide future studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.