Evidence map›Paper›PMID 41904124›Full record

ArticleNature communications2026

IL-22 induces Paneth cell metaplasia in the colonic epithelium of ulcerative colitis, promoting wound healing via REG3A.

Tomohiro Muto, Go Ito, Hiromune Katsuda, Yui Hiraguri, Satoru Fujii, Kurara Yamamoto, Joana P Bernardes, Finn Hinrichsen, Hitoshi Uchida, Yasuhiro Nemoto and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Colonic epithelial regeneration shapes susceptibility tobioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Tomohiro Muto *Department of Gastroenterology and Hepatology, Institute of Science Tokyo, Tokyo, Japan.ORCID http://orcid.org/0009-0005-9403-9743
Go Ito *Department of Gastroenterology and Hepatology, Institute of Science Tokyo, Tokyo, Japan. gito.gast@tmd.ac.jp.ORCID http://orcid.org/0009-0004-7488-0335
Hiromune KatsudaDepartment of Gastroenterology and Hepatology, Institute of Science Tokyo, Tokyo, Japan.ORCID http://orcid.org/0009-0006-4128-534X
Yui HiraguriDepartment of Gastroenterology and Hepatology, Institute of Science Tokyo, Tokyo, Japan.
Satoru FujiiDepartment of Gastroenterology and Hepatology, Institute of Science Tokyo, Tokyo, Japan.ORCID http://orcid.org/0009-0003-2220-0484
Kurara YamamotoDepartment of Human Pathology, Institute of Science Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0002-5272-6458
Joana P BernardesInstitute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein, Kiel, Germany.ORCID http://orcid.org/0009-0005-1429-8412
Finn HinrichsenInstitute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein, Kiel, Germany.ORCID http://orcid.org/0009-0002-6952-7348
Hitoshi UchidaDepartment of Gastroenterology and Hepatology, Institute of Science Tokyo, Tokyo, Japan.ORCID http://orcid.org/0009-0006-1474-773X
Yasuhiro NemotoDepartment of Gastroenterology and Hepatology, Institute of Science Tokyo, Tokyo, Japan.ORCID http://orcid.org/0009-0009-7619-2356
Mayumi KinoshitaDepartment of Clinical Laboratory Medicine, Faculty of Health Science Technology, Bunkyo Gakuin University, Tokyo, Japan.
Eri OshinaDepartment of Gastroenterology and Hepatology, Institute of Science Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0001-5289-1245
Kouhei YamamotoDepartment of Human Pathology, Institute of Science Tokyo, Tokyo, Japan.
Shuji HibiyaDepartment of Gastroenterology and Hepatology, Institute of Science Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0001-8823-7755
Sayaka NagataDepartment of Gastroenterology and Hepatology, Institute of Science Tokyo, Tokyo, Japan.
Fenja SchuranInstitute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein, Kiel, Germany.
Shiro YuiCenter for Stem Cell and Regenerative Medicine, Institute of Science Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0003-4268-647X
Penelope PelczarI. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Samuel HuberI. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0001-9325-8227
Stefan SchreiberInstitute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein, Kiel, Germany.ORCID http://orcid.org/0000-0003-2254-7771
Philip RosenstielInstitute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein, Kiel, Germany.ORCID http://orcid.org/0000-0002-9692-8828
Mamoru WatanabeOrganoid Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan.ORCID http://orcid.org/0000-0002-5475-9544
Ryuichi OkamotoDepartment of Gastroenterology and Hepatology, Institute of Science Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0002-7047-571X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paneth cell metaplasia (PCM) is a phenomenon in which Paneth cells, typically found in the small intestine, appear in the colonic epithelium of patients with ulcerative colitis (UC). Our study demonstrates that the PCM occurrence correlates with disease duration and active inflammation. Furthermore, we identified IL-22, an inflammation-associated cytokine, as a key regulator that promotes PCM formation in the colonic epithelium through suppression of Notch signaling and induces REG3A expression within metaplastic niches. In vitro, we show that Reg3a directly enhances cell proliferation and promotes wound healing using mouse colonic organoids. In vivo, Reg3a

Indexed as

Colitis, UlcerativeInterleukinsIntestinal MucosaPancreatitis-Associated ProteinsPaneth CellsWound HealingAnimalsCell ProliferationColonDextran SulfateDisease Models, AnimalFemaleHumansInterleukin-22MaleMetaplasiaDextran SulfateInterleukin-22InterleukinsPancreatitis-Associated ProteinsReceptors, NotchREG3A protein, humanReg3a protein, mouse

Identifiers

PMID41904124
PMCPMC13195176

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.