Evidence map›Paper›PMID 41903909›Full record

ArticleJournal of cardiac failure2026

Patiromer for Patients With Heart Failure at Risk of Hyperkalemia: CARE-HK in HF Registry.

Omar Cantu-Martinez, Stephen J Greene, Khaja M Chinnakondepalli, Stefan D Anker, Biykem Bozkurt, Javed Butler, John G Cleland, Nihar Desai, Diederick E Grobbee, Ellie Kelepouris and 6 more

Registry-linked trialAbstract read
In one paragraph

Article in Journal of cardiac failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04864795 (Cardiovascular and Renal Treatment in Heart Failure Patients With Hyperkalaemia or at High Risk of Hyperkalaemia), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04864795 completednot on this map

Cardiovascular and Renal Treatment in Heart Failure Patients With Hyperkalaemia or at High Risk of Hyperkalaemia (CARE-HK in HF Registry)

Typeobservational_patient_registrySponsorVifor (International) Inc.Ran2021 to 2024Enrolled2,636ConditionsHeart Failure, Hyperkalemia
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Omar Cantu-MartinezSaint Luke's Mid America Heart Institute and University of Missouri, Kansas City, Missouri.
Stephen J GreeneDuke Clinical Research Institute, Durham, North Carolina; Division of Cardiology, Duke University School of Medicine, Durham, North Carolina.
Khaja M ChinnakondepalliDepartment of Cardiology (CVK) of German Heart Center Charité, German Centre for Cardiovascular Research (DZHK) partner site Berlin, Charité Universitätsmedizin, Berlin, Germany.
Stefan D AnkerDepartment of Cardiology (CVK) of German Heart Center Charité, German Centre for Cardiovascular Research (DZHK) partner site Berlin, Charité Universitätsmedizin, Berlin, Germany.
Biykem BozkurtWinters Center for Heart Failure Research, Cardiovascular Research Institute, Baylor College of Medicine, Houston, Texas.
Javed ButlerBaylor Scott and White Research Institute, Dallas, Texas; University of Mississippi, Jackson, Mississippi.
John G ClelandSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Nihar DesaiSection of Cardiovascular Medicine, Yale School of Medicine, Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, Connecticut.
Diederick E GrobbeeJulius Global Health, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht University, Utrecht, the Netherlands.
Ellie KelepourisDivision of Renal Electrolyte and Hypertension, University of Pennsylvania, Philadelphia, Pennsylvania.
Giuseppe RosanoDepartment of Human Sciences and Promotion of Quality of Life, San Raffaele Open University of Rome, Rome, Italy; IRCCS, San Raffaele Roma, Italy.
Tibor KempfDepartment of Cardiology and Intensive Care Medicine, Städtisches Klinikum Braunschweig, Braunschweig, Germany.
Martin SchulzDepartment of Medicine, ABDA - Federal Union of German Associations of Pharmacists, and Institute of Pharmacy, Freie Universität Berlin, Berlin, Germany.
Carla-Maria BrandesCSL Vifor, Glattbrugg, Switzerland.
Victoria DonachieCSL Vifor, Glattbrugg, Switzerland.
Andrew J SauerSaint Luke's Mid America Heart Institute and University of Missouri, Kansas City, Missouri. Electronic address: asauer@saint-lukes.org.

Funding

CARDIOVASCULAR OUTCOMES RESEARCH TRAINING PROGRAMT32HL110837 · NHLBI · UNIVERSITY OF MISSOURI KANSAS CITY · PI JOHN A SPERTUS · 2012 to 2026
$5.0M
NHLBI NIH HHS T32 HL110837
6 · The paper itself

Abstract

backgroundFor patients with heart failure (HF), hyperkalemia (HK) may prevent optimal renin-angiotensin system inhibitor (RASi) use. Randomized trials show that patiromer, a contemporary potassium binder, reduces serum potassium (sK METHODS AND

resultsThe CARE-HK in HF (Cardiovascular and Renal Treatment in HF Patients with HK or at High Risk of HK) (NCT04864795) was a prospective registry of patients with chronic HF at increased risk of HK (prior or current HK or estimated glomerular filtration rate of <45 mL/min/1.73 m²). Patients treated with patiromer were propensity score matched with others not receiving potassium binders. HK episodes, sK

conclusionsIn contemporary clinical practice, patiromer was associated with reducing sK

Indexed as

chronic kidney diseaseheart failureHyperkalemiapatiromerRASi optimizationserum potassium

Identifiers

PMID41903909
PMCPMC13592558

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.