Evidence map›Paper›PMID 41903549›Full record

ArticleImmunity2026

NF-κB-activated fibroblasts orchestrate inflammaging and emergence of pro-inflammatory granzyme K

Nancy C Allen, Christian Ringler, Sang Ho Woo, Sophie Phipps, Jin Young Lee, Nabora Reyes, Ritusree Biswas, Lucile Neyton, Andrew Willmore, Sofia Caryotakis and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Nancy C AllenDepartment of Medicine, San Francisco, CA, USA; Bakar Aging Research Institute, San Francisco, CA, USA.
Christian RinglerDepartment of Medicine, San Francisco, CA, USA.
Sang Ho WooDepartment of Medicine, San Francisco, CA, USA.
Sophie PhippsDepartment of Medicine, San Francisco, CA, USA.
Jin Young LeeDepartment of Medicine, San Francisco, CA, USA; Bakar Aging Research Institute, San Francisco, CA, USA.
Nabora ReyesDepartment of Medicine, San Francisco, CA, USA; Bakar Aging Research Institute, San Francisco, CA, USA.
Ritusree BiswasDepartment of Medicine, San Francisco, CA, USA; Bakar Aging Research Institute, San Francisco, CA, USA.
Lucile NeytonDepartment of Medicine, San Francisco, CA, USA.
Andrew WillmoreDepartment of Medicine, San Francisco, CA, USA.
Sofia CaryotakisImmunoX Initiative and Biomedical Sciences Graduate Program, San Francisco, CA, USA; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Jessica RoginskyImmunoX Initiative and Biomedical Sciences Graduate Program, San Francisco, CA, USA; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Lu GuoDepartment of Medicine, San Francisco, CA, USA.
Melia MagnenDepartment of Medicine, San Francisco, CA, USA; ImmunoX Initiative and Biomedical Sciences Graduate Program, San Francisco, CA, USA.
Pedro RuivoComparative Pathology Laboratory, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA.
Chaz LangelierDepartment of Medicine, San Francisco, CA, USA.
COMET ConsortiumDepartment of Medicine, San Francisco, CA, USA.
Mark LooneyDepartment of Medicine, San Francisco, CA, USA; ImmunoX Initiative and Biomedical Sciences Graduate Program, San Francisco, CA, USA.
Averil MaDepartment of Medicine, San Francisco, CA, USA; ImmunoX Initiative and Biomedical Sciences Graduate Program, San Francisco, CA, USA.
Vincent AuyeungDepartment of Medicine, San Francisco, CA, USA.
Carolyn CalfeeDepartment of Medicine, San Francisco, CA, USA.
Ari B MolofskyImmunoX Initiative and Biomedical Sciences Graduate Program, San Francisco, CA, USA; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Tien PengDepartment of Medicine, San Francisco, CA, USA; Bakar Aging Research Institute, San Francisco, CA, USA; ImmunoX Initiative and Biomedical Sciences Graduate Program, San Francisco, CA, USA. Electronic address: tien.peng@ucsf.edu.

Funding

UC San Diego FIRST ProgramU54CA272220 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MARIA ELENA MARTINEZ, Joann Trejo · 2022 to 2026
$21.2M
Restorative practice in repairing harm and promoting safe and inclusive practices in the laboratory.T32GM136547 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Adrian Erlebacher, Anita Sil · 2020 to 2026
$4.5M
Localization and function of tissue type 2 lymphocytes during mixed inflammationR01AI162806 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Ari B Molofsky · 2022 to 2026
$2.8M
Deciphering the role of p16INK4A+ fibroblasts in lung fibrosisR01HL160895 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PENG, TIEN · 2022 to 2025
$2.2M
Role of stromal inflammatory signaling in the aging of lung resident lymphocytesK08HL169723 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Nancy Christine Allen · 2023 to 2026
$676k
Mesenchymal inflammatory signaling in regulation of the immune response and tissue dysfunction during lipopolysaccharide-induced acute lung injuryF32HL156452 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALLEN, NANCY CHRISTINE · 2022 to 2023
$103k
NCI NIH HHS U54 CA272220NHLBI NIH HHS F32 HL156452NHLBI NIH HHS K08 HL169723NHLBI NIH HHS R01 HL160895NIAID NIH HHS R01 AI162806NIGMS NIH HHS T32 GM136547
6 · The paper itself

Abstract

While inflammaging supposedly drives some of the most common diseases affecting the elderly, little is known about the tissue drivers of inflammaging. In this study, we demonstrate that age-dependent activation of nuclear factor κB (NF-κB) in tissue fibroblasts remodeled the immune architecture, promoting the emergence of an exhausted granzyme K (GZMK)

Indexed as

AgingCD8-Positive T-LymphocytesFibroblastsGranzymesInflammationNF-kappa BAnimalsCells, CulturedHumansLungMacrophagesMiceMice, Inbred C57BLT-Cell ExhaustionGranzymesNF-kappa BadventitiaARDSfibroblastsGZMK+ T cellsimmune aginginflammaginglungNF-κBT cell exhaustiontertiary lymphoid structureTNFAIP3

Identifiers

PMID41903549
PMCPMC13309925

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.