ArticleImmunity2026
Krüppel-like factors 2 and 3 regulate T cell exhaustion by directing T cell residency and migration.
Abstract read
In one paragraph
Article in Immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Plasma Cell Selection and Migration in the Establishment of Long-Lived Antibody Responses.Immunological reviews · 2026Review
- The atypical IκB factor IκBδ enhances CD8 T cell accumulation and effector functions in solid tumors.bioRxiv : the preprint server for biology · 2026Article
- Lymphatic egress recycles tumor-experienced effector CD8 T cells to sustain immune surveillance.bioRxiv : the preprint server for biology · 2026Article
- Functions and features of circulating memory T cells.Immunity · 2026Review
- Non-redundant functions of NFATc1 in survival and NFATc2 in generation of exhausted CD8Frontiers in immunology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Jian ShenDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Center for Human Immunobiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Ryan J BrownDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Center for Human Immunobiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Department of Microbiology & Immunology, Medical College of Wisconsin, Milwaukee, WI, USA.
Yuqi ZhangDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Center for Human Immunobiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Kexin GaiDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Center for Human Immunobiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Ashley K BrownDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Center for Human Immunobiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Department of Microbiology & Immunology, Medical College of Wisconsin, Milwaukee, WI, USA.
Ashley M BauerDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Center for Human Immunobiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Ashley ZhuDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Siying LinDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Center for Human Immunobiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Department of Microbiology & Immunology, Medical College of Wisconsin, Milwaukee, WI, USA.
Hongshen NiuDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Center for Human Immunobiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Arjun KharelDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Center for Human Immunobiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Ziyang XuDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Gregory S CohenDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Center for Human Immunobiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Taylor A DepauwUniversity of Minnesota Medical School, Minneapolis, MN, USA.
Eric FagerbergDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Geoffrey S KansasCenter for Human Immunobiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Nikhil S JoshiDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Stephen C JamesonUniversity of Minnesota Medical School, Minneapolis, MN, USA.
Weiguo CuiDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Center for Human Immunobiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Electronic address: weiguo.cui@northwestern.edu.
Funding
CARCINOGENESIS TRAINING PROGRAMT32CA009560 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Kathleen Janee Green · 1986 to 2026
$8.4MMedical Scientist Training ProgramT32GM080202 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI BARBIERI, JOSEPH T, SALZMAN, NITA H · 2010 to 2024
$5.7MPhenotypic, Functional and Transcriptional Heterogeneity in T Cell ExhaustionR01AI148403 · NIAID · VERSITI WISCONSIN, INC. · PI WEIGUO CUI · 2020 to 2026
$3.1MHuman and Translational Immunology Training ProgramT32AI155387 · NIAID · YALE UNIVERSITY · PI Joseph Edgar Craft, Kevan C Herold · 2021 to 2026
$2.6MTCR signaling regulated T cell exhaustion in response to chronic viral infectionR01AI189723 · NIAID · NORTHWESTERN UNIVERSITY · PI WEIGUO CUI · 2025 to 2026
$1.3MHigh-throughput discovery of novel transcriptional programs regulating T cell exhaustionR21AI180877 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CUI, WEIGUO · 2024 to 2025
$434kTCR signaling strength regulated T cell differentiation during chronic viral infectionR56AI176611 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CUI, WEIGUO · 2024 to 2024
$350kNCI NIH HHS T32 CA009560NIAID NIH HHS R01 AI148403NIAID NIH HHS R01 AI189723NIAID NIH HHS R21 AI180877NIAID NIH HHS R56 AI176611NIAID NIH HHS T32 AI155387NIGMS NIH HHS T32 GM080202
Abstract
During chronic viral infection, CD8
Indexed as
CD8-Positive T-LymphocytesCell MovementKruppel-Like Transcription FactorsAnimalsCell DifferentiationHumansMiceT-Cell ExhaustionKlf2 protein, mouseKruppel-Like Transcription Factorschromatin accessibilitychronic viral infectionKLF2KLF3sphingosine-1-phosphate signalingT cell differentiationT cell exhaustionT cell migrationtissue residencytranscriptional regulation
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.